伪异胞苷类化合物的合成  

Studies on the Synthesis of Analogues of Pseudoisocytidine

作　　者：董领娇 张东[1] 欧阳军 王瑜[1] 马灵台 张礼和[1] 

机构地区：[1]北京医科大学药学院,北京100083

出　　处：《高等学校化学学报》1993年第9期1235-1238,共4页Chemical Journal of Chinese Universities

基　　金：国家自然科学基金

摘　　要：利用Wittig反应合成了一系列伪异胞苷类化合物,通过改进实验条件提高了关键中间体的收率,并深入研究了保护的核糖甲氧基丙烯酸乙酯与各种取代的胍和脒的缩合条件.A series of analogues of pseudoisocytidine were synthesized via Witting reaction. We successfully raised the yields of the key-intermediates(Ⅵ ) by improving the experimental procedure, and also investigated profoundly the condensing condition of Ⅵ with some sorts of guani-dines and amidines.

关 键 词：伪异胞苷 WITTIG反应 碳核苷 

分 类 号：TQ463.5[化学工程—制药化工]