转录因子MEF2对多种信号通路的调节及其生物学作用  

Regulation of Transcriptional Factor MEF2 to Multiple Signal Conduction Pathways and Biological Functions

作　　者：张文炜[1] 徐列明[1] 

机构地区：[1]上海中医药大学肝病研究所曙光医院,上海201203

出　　处：《中国生物化学与分子生物学报》2004年第4期423-427,共5页Chinese Journal of Biochemistry and Molecular Biology

基　　金：国家自然科学基金资助项目 (No.3 0 2 7165 7);美国布朗大学合作项目~~

摘　　要：肌细胞增强因子 2 (myocyteenhancerfactor 2 ,MEF 2 )是一种特定的转录因子 .由于其涉及基因调节的不同环节及其多样的控制基因表达和功能的调节机制 ,正日益受到高度的重视 .目前发现MEF2最突出的功能是控制肌细胞分化过程中的基因转录 ,其主要作用是在骨骼肌、心肌和平滑肌的发育过程中介导细胞的分化 .MEF2作为钙依赖性调节因子 ,在神经系统的发育和分化中也发挥着重要的作用 .近来实验发现 ,MEF2可能参与肝脏纤维化的形成过程 ,是肝星状细胞 (hepaticstellatecell,HSC)Myocyte enhancer factor (MEF2) are specific transcription factors, and are fascinating due to their involvement in diverse functions of gene regulation and the multiplicity of regulatory mechanisms. The apparent ability of MEF2 is to control the transcription of genes in muscle differentiation. The main functions are to mediate differentiation during the development of skeletal, cardiac, smooth muscle. As calcium regulated factors, MEF2 plays an important role in the neuronal survival and differentiation. Recently,MEF2 factors are shown to participate in the process of liver fibrosis and may be an important regulatory factor during hepatic stellate cell activation.

关 键 词：肌细胞增强因子 调节 转录因子 肝纤维化 

分 类 号：Q51[生物学—生物化学]