脂肪组织的免疫功能  

The Immune Function of Adipose Tissue

作　　者：周一然[1] 宋建国[1] 

机构地区：[1]中国科学院生物化学与细胞生物学研究所,上海200031

出　　处：《生物化学与生物物理进展》2004年第8期679-683,共5页Progress In Biochemistry and Biophysics

摘　　要：脂肪组织不仅是能量的储备器官 ,也是一个重要的内分泌器官 .它协助神经系统和其他内分泌器官维持机体的内平衡 .近年来 ,一些研究表明脂肪组织与免疫反应有着密切的联系 .人们发现脂肪细胞分泌的瘦素不仅调节机体的能量代谢和控制脂肪的积累 ,还参与调节单核细胞、巨噬细胞和淋巴细胞的免疫功能 ,是一种作用广泛的细胞因子 .脂肪细胞分泌的其他因子如脂联素也有免疫调节作用 .免疫刺激还会作用于淋巴结周围的脂肪组织 ,引起这些脂肪细胞发生脂解作用 .脂肪组织与免疫系统的相互作用 ,进一步表明生命是由各系统组成的一个有机统一体 .随着对这一领域的研究不断深入 。Adipose tissue is not only an energy storage organ but also an important endocrine organ. It assists nerve system and other endocrine organs to maintain body homoeostasis. In recent years, some studies suggested a tight relationship between adipose tissue and immunity. Leptin, a hormone secreted by mature adipocyte which functions in regulating not only energy metabolism and body fat mass but also the immune effects of monocyte, macrophage, and lymphocytes. Adiponectin, another factor secreted by adipose tissue, can also regulate the immune responses of cells. In addition, immune stimulation can induce lipolysis of fat depot around lymph node. The interaction between adipocyte and immune system further demonstrates that the living body is an intergrated organic unity. The advancement in this area of study would likely provide new perspectives to therapeutic methods on related diseases.

关 键 词：脂肪组织 免疫功能 内分泌器官 瘦素 细胞因子 免疫细胞 

分 类 号：R392[医药卫生—免疫学] Q493.5[医药卫生—基础医学]