急性心肌梗死病人肌钙蛋白I含量与梗死面积和部位的关系  

Relationship between cTnI's Content and Infarctional Area and Position in Acute Myocardium Infarction Patient

作　　者：唐浩熙[1] 李介华[2] 夏明凯[2] 张小勇[2] 李冬秀[2] 梁大立[2] 岑欢[2] 陆灶其[2] 

机构地区：[1]暨南大学医学院第五附属医院暨广东省清远市人民医院 [2]广东省清远市人民医院

出　　处：《中西医结合心脑血管病杂志》2004年第7期375-376,共2页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：广东省清远市科技计划项目 (No .2 0 0 4 1 72 1 )

摘　　要：目的　探讨急性心肌梗死(AMI)病人的肌钙蛋白I(cTnI)的含量与梗死面积和部位的关系 ,以评估AMI的病情程度及预后。方法　健康对照组 60例 ,于 0 9:0 0空腹抽静脉血 3ml,分离血清。AMI组 5 8例 ,于胸痛发作后 3h、6h、9h、12h时抽静脉血 3ml,分离血清。cTnI采用化学发光免疫分析法 (CLIA)定量检测。肌酸激酶同工酶 (CK -MB)采用连续监测法定量检测。结果　急性广泛前壁梗死病人的cTnI含量与对照组及急性前壁、间壁梗死、急性下壁、侧壁梗死组比较有统计学意义 (P <0 .0 1) ,与急性非Q波性梗死组比较无统计学意义 (P >0 .0 5 )。cTnI含量与CK -MB有良好的相关性。结论　用CK -MB计算梗死面积已得到病理和临床证实。cTnI含量与CK -MB有良好的相关性 ,说明cTnI含量越高AMI病人的梗死面积越大。实验结果表明 ,cTnI含量与AMI病人的梗死面积呈正相关 ,与梗死部位无明显相关性。Objective In order to evaluate state of an illness and prognosis of patients with acute myocardium infarct( AMI) ,To probe into relationship between the contents of troponin I( cTnI) and infarct area and place.Methods To draw fasting venous blood 3 ml from every persons of contrast group(60 health people) at 9 o'clock in the morning and separate the serum.AMI group is 58 people.To draw venous blood 3 ml after 3, 6, 9 , and 12 hours of chest aches breaking out and separate serum. The CTnI adopts the means of chemiluminescence immunoassay(CLIA).The CK-MB adopts series ration examination.Results The contents of cTnI of patients with acute abroad anterior wall infarct had statistical meaning to contrast group ,acute anterior wall infarct group,partition infarct group,inferior infarct group, and lateral infarct group(P<0.01).To has not statistical meaning to no Q wave infarct group(P>0.05). The contents of cTnI has good relativity with CK-MB.Conclusion To calculate the infarct area with CK-MB had been verified by pathology and clinic.Because cTnI has good relationship with CK-MB,the more cTnI the more infarc area.Experment result indicate that content of cTnI has positive correlation with infarct area of AMI patients,however has no evident correlation with infarct position.

关 键 词：急性心肌梗死 肌钙蛋白I 含量 梗死面积 梗死部位 预后 

分 类 号：R542.22[医药卫生—心血管疾病]