E-钙黏素及β-连环素在子宫内膜异位症中的表达  

Study on the expression of E-cadherin and β-catenin in endometrial and endometriotic tissues of patients with endometriosis

作　　者：王立宏[1] 李亚里[1] 刘爱军[1] 

机构地区：[1]解放军总医院,北京100853

出　　处：《解放军医学杂志》2004年第7期612-614,共3页Medical Journal of Chinese People's Liberation Army

基　　金：国家自然科学基金资助课题 (编号 39830 350 )

摘　　要：目的　观察E 钙黏素、β 连环素在子宫内膜异位症 (EM)患者在位内膜和异位内膜上皮的表达情况 ,研究其表达规律及在不同分期EM患者中的表达差异。方法　采用光镜、免疫组化SP法检测 2 4例EM患者在位和异位内膜及 2 1例健康对照在位内膜E 钙黏素、β 连环素的表达情况。结果　与正常子宫内膜相比 ,EM患者在位子宫内膜E 钙黏素、β 连环素周期性表达的规律性消失 ,且表达强度低于正常对照组 (P <0 0 5 )。EM患者异位子宫内膜E 钙黏素、β 连环素的表达高于在位子宫内膜 (P <0 0 5 )。Ⅰ、Ⅱ期患者异位子宫内膜E 钙黏素、β 连环素的表达明显低于Ⅲ、Ⅳ期 (P <0 0 5 )。结论　E 钙黏素、β 连环素在EM患者在位内膜、异位内膜上的表达异常 。Objective To study the expression of E-cadherin and β-catenin in endometrial and endometriotic tissues of patients with endometriosis (EM) and to compare their expression in endometriosis at different stages. Methods Twenty-four EM patients were enrolled and the expression of E-cadherin and β-catenin in endometrial and endometriotic tissues were determined by immunohistochemistry method. Normal endometrial tissue from 21 individuals was included as the control group. Results Compared with the control group, in E-cadherin and β-catenin expression was shown in no difference between the secretory and the proliferative phase of endometrial tissue from EM patients. Furthermore, the expressions of E-cadherin and β-catenin in normal endometrial tissue were stronger than that of EM patients(P<0.05).In EM patients, expressions of both E-cadherin and β-catenin in endometriotic tissue was stronger than that of endometrial tissue(P<0.01).In EM at different stages, expressions in both stage Ⅰ and Ⅱ were weaker than that of stage Ⅲ and IV(P<0.05). Conclusions The abnormal expression of E-cadherin andβ-catenin in endometriotic and endometrial tissues has close relationship with the etiology of endometriosis. They may play different roles at different stages of endometriosis.

关 键 词：Β连环素 上皮细胞钙黏素 免疫组织化学 子宫内膜异位症 

分 类 号：R714[医药卫生—妇产科学]