育龄期妇女体内有机污染物成分的鉴定与分析  

Identification and Analysis of Organic Pollutants in Child-Bearing Age Women Body

作　　者：刘慧杰[1] 舒为群[1] 张学奎[2] 梁志清[3] 常青[3] 江露[3] 

机构地区：[1]第三军医大学环境卫生学教研室,重庆400038 [2]重庆市疾病预防控制中心,重庆400042 [3]第三军医大学西南医院妇产科,重庆400038

出　　处：《环境与健康杂志》2004年第4期228-230,共3页Journal of Environment and Health

基　　金：国家科技部攻关项目(2003DA903B03-02B);国家科技部西部引导项目(2003BA869C)

摘　　要：目的了解育龄期妇女体内有机物污染状况,评估其对妇女及后代健康的危害。方法选择年龄在23～32岁健康妇女8人,分别采集全血及尿样,经正己烷萃取有机物后,利用气相色谱-质谱(GC-MS)仪进行有机物的定性分析。结果血样中共检出有机物34种,人均(8.63±5.01)种;检出频率较高的为邻苯二甲酸二丁酯(100%)、14-β-孕激素(75.0%)等。尿样中共检出有机物39种,人均(11.63±1.30)种,检出频率较高的为邻苯二甲酸二丁酯(100%)、HAHNFETT(100%)、14-β-孕激素(87.5%)、二十二烷(87.5%)、邻苯二甲酸二异丁酯(75.0%)等。在所检出的化合物中部分为环境有毒污染物。结论育龄期妇女体内存在环境污染物,其中邻苯二甲酸酯类物质检出频率较高。它们对人群健康的潜在危害应当引起重视。Objective To investigate the exposure levels of organic pollutants in child-bearing age women body. Methods The blood and urine specimens were collected simultaneously from each of 8 health women, aged 23-32 years, the organics were extracted with hexane and determined qualitatively by gas chromatography-mass spectrometer (GC-MS) for each specimen. Results In blood, 34 kinds of organic compounds had been detected , at average of (8.63±5.01 )kinds per person. Di-n-butyl phthalate (100%) and 14-bate-H-pregna (75.0%) revealed the highest detectable rates. In urine, 39 kinds of organic compounds had been identified, at average of (10.63±1.30) kinds per person, di-n-butyl phthalate(100%), HANFETT(100%), 14-bate-H-pregna(87.5%), docosane (87.5%), di-isobutyl phthalate(75.0%) were the chemicals noticed more frequently. Some kinds of these identified organics compounds were environmental toxic pollutants. Conclusion This study suggested that toxic organic pollutants had existed in child-bearing age women body, phthalic acid esters were the chemicals checked out more frequently. Their potential adverse health effects on women and offspring should be paid highly attention to.

关 键 词：妇女 有机化学物 邻苯二甲酸酯类 

分 类 号：R181.3[医药卫生—流行病学]