应用卵黄蛋白原检测内分泌干扰物质的研究进展  

Current Status of Using Vitellogenin as A Biomarker to Screen Endocrine Disruptors

作　　者：宋福永[1] 李杰[1] 

机构地区：[1]山东大学劳动卫生与环境卫生研究所,山东济南250012

出　　处：《环境与健康杂志》2004年第4期264-266,共3页Journal of Environment and Health

基　　金：国家自然科学基金资助项目(30070646)

摘　　要：由于内分泌干扰物对人类健康及生物种群的严重影响,已经成为当前公共卫生和环境保护研究工作的一个热点。该文介绍了卵黄蛋白原作为内分泌干扰物筛选生物标志物的科学依据和优势,并在此基础上综述了卵黄蛋白原及其编码基因表达的检测方法及原理、应用和优缺点。As harmful effect on human healh and on existence of biological population etiological system may caused by endocrine disruptors, it has become the focus of many studies of public health and environmental protection. This paper briefly summarized the current status of studies on the definition, classification, adverse effects and screening methods of endocrine disruptors, and also reviewed the scientific theory and advantages of vitellogenin that was qualified as a biomarker in screening environmental endocrine disruptors. On the basis of the matters mentioned above, the paper specifically introduced the principle, application, merits and shortcomings for methods for detecting vitellogenin protein and its encoding gene.

关 键 词：内分泌干扰物 卵黄蛋白原 生物标记物 

分 类 号：R994.6[医药卫生—毒理学]