蒙脱石散对部分喹诺酮类药物的体外吸附作用  

Adsorption of montmorillonite powder with quinolone agents in vitro

作　　者：常威[1] 

机构地区：[1]兰州医学院第一附属医院,甘肃兰州730000

出　　处：《中国医院药学杂志》2004年第5期268-269,共2页Chinese Journal of Hospital Pharmacy

基　　金：甘肃省自然科学基金项目 (编号 :ZS0 2 1-A2 5 -0 74-Y)

摘　　要：目的 :比较在人工胃液和水溶液中蒙脱石散对常用剂量的喹诺酮类药物吡哌酸、诺氟沙星、氧氟沙星、盐酸环丙沙星、甲磺酸培氟沙星、盐酸洛美沙星的吸附作用。方法 :取蒙脱石散分别加入到上述药物的水溶液和人工胃液中 ,用紫外分光光度法测定药物含量 ,计算吸附率。结果 :在水溶液中吡哌酸、诺氟沙星、氧氟沙星极微溶。在人工胃液中 ,药物质子化程度提高 ,表现为阳离子特性 ,蒙脱石对其吸附率达 98.6 %以上。盐酸环丙沙星、甲磺酸培氟沙星、盐酸洛美沙星已与酸成盐 ,无论在水溶液还是在人工胃液中 ,蒙脱石对其的吸附率达 99%以上。结论 :蒙脱石对常用剂量的喹诺酮类药物有强大的吸附作用 ,服用上述药物应在服用蒙脱石散之后 1～ 2h。OBJECTIVE To compare adsorption effects of smecta in artificial gastric fluid with that in water to pipemidic acid, norfloxacin, ofloxacin,ciprofloxacin hydrochloride, pefloxacin mesyl and lomefloxacin hydrochloride. METHODS Smecta was added to the solutions of above drugs respectively, the adsorption rates were measured by UV. RESULTS Pipemidic acid, norfloxacin, ofloxacin were insoluble in water,but dissolved in artifical with increased proton characteristic, adsorption rates of them by smecta were over 98.6%. Ciprofloxacin hydrochloride,pefloxacin mesyl,lomefloxacin hydrochloride were salts, adsoption rates of them in water or in artifical gastric fluid were all more than 99%. CONCLUSION The adsorption gastric fluid effects of smecta normal usual dose of quinolone agents is very strong,the drugs should be administered after taking smecta 1～2 hours later.

关 键 词：蒙脱石散 配伍 喹诺酮类药物 吸附作用 

分 类 号：R969.2[医药卫生—药理学]