东北菱提取物对肝癌细胞的体内外抑制作用  

Inhibitory effects of extracts from Trapa manshurica Fler. on liver cancer cells in vivo and in vitro

作　　者：牛凤兰[1] 李晨旭[1] 董威严[1] 程舸[1] 曲扬[2] 

机构地区：[1]吉林大学公共卫生学院中心实验室,吉林长春130021 [2]吉林大学图书馆,吉林长春130021

出　　处：《吉林大学学报（医学版）》2004年第4期553-555,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅资助课题 (2 0 0 10 5 6 0 )

摘　　要：目的 :探索东北菱提取物对肝癌细胞体内外抑制作用。方法 :采用 3H- Td R掺入法分别测定东北菱醇提取物和水提取物对肝癌细胞的体外敏感性 ;对荷瘤小鼠进行体内实验 ,观察该提取物对肝癌细胞生长的抑制率。结果 :体外实验当剂量达 2 2 5 .0 0 g· L- 1 时 ,抑制率为 75 .4 9% ;体内实验抑瘤率为 6 0 %以上。结论 :东北菱不同溶剂提取物均具有抑制肝癌细胞的作用。Objective To explore the inhibitory effects of extracts from Trapa manshurica Fler. on liver cancer cells in vivo and in vitro. Methods The sensitivity of extracts from Trapa manshurica Fler. to liver cancer cells in vitro was determined with 3H-TdR incorporation method. The inhibitory rate and growth of the tumor and the weight change of the mice were observed. Results When the dosage was 225.00 g·L -1, the inhibitory rate of tumor was 75.49% in vitro and the inhibitory rate of tumor was 60% in vivo. Conclusion The extracts from Trapa manshurica Fler. has the inhibitory effects on tumor.

关 键 词：东北菱 肝肿瘤  实验性/药物疗法 肝癌细胞 

分 类 号：R979.1[医药卫生—药品]