2450MHz微波辐射对大鼠海马长时程增强和脑组织脂褐素的影响  

Effects of 2 450 MHz Microwave on Long-term Potentiation of Hippocampus and Lipofuscin Contents in Rat Brain.

作　　者：赵亚丽[1] 彭小东[2] 杨玉华[1] 马洪波[1] 宋锦萍[1] 浦京遂[1] 

机构地区：[1]航天医学工程研究所,北京100094 [2]军事医学科学院药物毒物研究所,北京100850

出　　处：《航天医学与医学工程》2004年第2期111-113,共3页Space Medicine & Medical Engineering

基　　金：总装备部试验技术课题 ( 0 1965 0 1)

摘　　要：目的探讨微波对学习记忆影响的作用机制。方法对海马诱发电位的长时程增强 (LTP)和脑脂褐素含量进行研究 ,用 2 4 5 0MHz微波理疗机为照射源 ,以大鼠为实验对象 ,分别采用在体海马诱发电位法和分光光度法。结果 1 0 2 5mW/cm2 强度范围内的连续微波 ,可以对弱条件刺激和强条件刺激引发的LTP的群峰电位 (PS)峰值产生抑制作用 ,并存在强度 -效应关系 ,在 2 5mW/cm2 时脂褐素含量显著高于对照组和 1 0mW/cm2 组 (P <0 .0 5 )。结论 1 0 2 5mW/cm2 强度范围内的 2 4 5 0MHz连续微波可以通过抑制海马LTP的生成和脑脂褐素含量增加 ,造成学习记忆损害。Objective To study the mechanism of the effects of microwave on learning and memory. Method Long-term potentiation(LTP) of hippocampus induced potential and lipofuscin content in rat brain were studied.After irradiated by a 2 450 MHz microwave,rats hippocampus induced potential in vivo was recorded and lipofuscin content in the brain was measured by fluorospectrophotometry. Result Continuous microwave with 10~ 25 mW/cm 2 intensity could inhibit the amplitude of the population spike(PS) of weak and strong stimuli induced LTP with an intensity–effect relationship. At 25 mW/cm 2, lipofuscin content was signifcantly higher than control and 10 mW/cm 2 group(P<0.05). Conclusion Continuous microwave with 10~ 25 mW/cm 2 intensity impairs learning and memory by restraining hippocampus LTP and brain lipofuscin content.

关 键 词：微波辐射 海马 长时程增强 脂褐素 学习 记忆 

分 类 号：R832.7[医药卫生—航空、航天与航海医学] R594.8[医药卫生—临床医学]