四种新型饮水的安全性评价及其对小鼠免疫功能的影响  

Safety assessment and effect of new-type drinking water on immunity in mice

作　　者：宋瑞霞[1] 邢淑霞[1] 白雪涛[1] 

机构地区：[1]中国疾病预防控制中心环境健康与相关产品安全所,北京100021

出　　处：《卫生研究》2004年第4期419-421,共3页Journal of Hygiene Research

基　　金：科技部基金"饮用水卫生标准;检测与评价"分课题"特种水的安全性评价"

摘　　要：目的　评价纯净水、矿溶水、活化水、碱性离子水的安全性并探讨其对小鼠免疫功能的影响。方法　以急性经口毒性试验、Ames试验、微核试验、小鼠精子畸形试验测定 4种新型饮水的急性毒性和遗传毒性 ;以绵羊红细胞 (SRBC)诱导小鼠DTH之足跖增厚法、Jerne改良玻片法测定小鼠抗体生成细胞数分别测定受试物对小鼠细胞免疫和体液免疫的影响。结果　 4种新型饮水对小鼠的急性经口毒性试验结果均属实际无毒级 ,三项遗传毒性试验结果均为阴性 ;与对照组比较 ,4种受试物组小鼠的DTH肿胀度、抗体细胞生成数均无明显改变 ,经统计学检验 ,差异无显著性。结论　 4种新型饮水未呈现遗传毒性 。Objective To assess the safety of four kinds new type drinking water and explore its effect on immunologic function in mice. Methods Its acute oral toxicity and Genotoxicity were detected using acute toxicity test, Ames test, micronucleus assay of mice bone marrow cell and mice sperm malformation test. Its effects on cellular, humoral immune function were assessed respectively by metatarsus thickening method, Jerne improved slide method. Results Its acute oral LD50 in mice were greater than 10000mg/kg BW, three genetic toxicity tests showed negative results, the metatarsa injected with SRBC and number of antibody forming cells were no evidently thicker in test group than in control group. Conclusion The result did not indicate the genotoxicity of the four kinds new type drinking water and they couldn't effect immunologic function in mice.

关 键 词：新型饮水 安全性评价 免疫功能 

分 类 号：R123.1[医药卫生—环境卫生学] R392.1[医药卫生—公共卫生与预防医学]