氨甲蝶呤及氨甲蝶呤配伍米非司酮治疗输卵管妊娠的对比研究  

Comparison of methotrexate alone and combined with mifepristone in treatment of tubal pregnancy

作　　者：张娟辉[1] 孔欣[1] 周新力[1] 龙波[1] 王彩霞[1] 李琴[1] 黄雪霞[1] 龚琳[1] 胡晴丽[1] 李玉玲[1] 

机构地区：[1]武警广东总队医院妇产科,广州510507

出　　处：《武警医学》2004年第7期501-503,共3页Medical Journal of the Chinese People's Armed Police Force

基　　金：武警部队科研基金资助项目 (WKH980 63 )

摘　　要：目的　比较单用MTX及MTX配伍米非司酮治疗输卵管妊娠的疗效。方法　 12 6例实验组肌注MTX 5 0mg及口服米非司酮 15 0mg;对照组 12 0例肌注MTX 5 0mg。结果　实验组成功 113例 ,成功率为 89.6 8% ;对照组成功 88例 ,成功率为73.33% ,二者统计学差异具有显著性 (P <0 .0 5 )。Fernandez评分 >12分者 ,实验组为 6 1.5 3% ,对照组为 2 7.2 7% ,差异具有显著性 (P <0 .0 5 )。结论　MTX和米非司酮的作用机制不同 ,联合用药具有协同作用 ,可提高治疗成功率 。Objective To evaluate the efficacy of MTX alone or combined with mifepristone in treating tubal pregnancy. Method Group A of 126 patients with tubal pregnancy were given 50 mg of MTX intramuscularly and 150 mg of mifepristone orally,whereas group B of 120 patients were administered 50 mg of MTX alone intramuscularly. Results The success rate in group A was 89.68% whereas that in group B was 73.33%,with a statistically significant difference.The patients with Fernandez's scores over 12 accounted for 61.53% in group A and 27.27% in group B. Conclusions Combined use of MTX and mifepristone has better efficacy than MTX alone in treating tubal pregnancy,suggesting the synergistic effect of the two drugs.

关 键 词：氨甲蝶呤 氨甲蝶呤 米非司酮 联合用药 药物治疗 输卵管妊娠 

分 类 号：R714.221[医药卫生—妇产科学]