血清中β淀粉样蛋白检测对老年性痴呆的临床意义  

Detection of Serum β Amyloid Protein and Its Clinical Significance in Senile Dementia

作　　者：崔玉琴[1] 卢建华[1] 李晓风[1] 王燕[1] 王强[1] 

机构地区：[1]包头市第七医院神经内科,内蒙古包头014030

出　　处：《内蒙古医学杂志》2004年第7期499-500,共2页Inner Mongolia Medical Journal

摘　　要：目的 :研究阿尔茨海默病 (AD)患者血清中 β淀粉样蛋白 (Aβ)含量及临床意义。方法 :采用放射免疫分析法 (RIA)检测 2 2例AD患者和 30例正常对照者血清中Aβ含量。结果 :AD患者血清中Aβ含量明显高于对照组 (P <0 0 5 ) ;以 72 3pg/ml作为正常人群Aβ含量的上限 ,诊断老年性痴呆的敏感性为6 3 6 % ,特异性为 83 3% ;经相关分析 ,血清Aβ含量与MMSE评分之间未发现显著相关关系 (P >0 0 5 )。结论 :AD患者血清中Aβ含量升高 ,对诊断老年性痴呆有较高的敏感性和特异性 ,有一定的临床应用价值。Objective:To detect the contents of serum β amyloid protein(Aβ) in patients with Alzheimer's disease(AD) and to evaluate its clinical significance.Method:The contents of serum Aβ of 22 AD and 30 controls were detected by radioimmunoassay (RIA).Result:The contents of serum Aβ in AD patients were significantly higher than that of normals(P<0.05).Supposing 72.3pg/ml as the upper limit level of normal serum Aβ,the sensitivity of serum Aβ in senile dementia was 63.6% and the specificity was 83.3%.There was no significant liner correlation between the contents of serum Aβ and the score of MMSE(P>0 05).Conclusion:The increasing serum Aβ in AD patients is sensitive and specific in diagnosis of senile dementia.It is valuable in clinical application.

关 键 词：老年性痴呆 血清 β—淀粉样蛋白 放射免疫分析 

分 类 号：R446.1[医药卫生—诊断学] R592[医药卫生—临床医学]