β-磷酸三钙多孔生物陶瓷植入体内后的组成变化  

COMPOSITION CHANGES OF βTRICALCIUM PHOSPHATE POROUS BIOCERAMICS AFTER IMPLANTATION IN VIVO

作　　者：戴红莲[1] 李世普[1] 闫玉华[1] 李小溪[1] 沈春华[1] 

机构地区：[1]武汉理工大学生物材料与工程研究中心,武汉430070

出　　处：《硅酸盐学报》2004年第7期800-807,共8页Journal of The Chinese Ceramic Society

基　　金：973"国家重点基础研究发展规划(G1999064701)资助项目

摘　　要：采用电子探针结合X射线能谱对多孔磷酸三钙陶瓷人工骨植入骨内后,材料/新骨界面、新骨的组成进行了检测。比较植入人工骨后不同阶段材料以及界面元素组成的变化,材料植入后骨缺损区新骨生成的情况。结果显示:随着植入时间的延长,新骨组织中碳元素含量不断降低,钙和磷元素的含量则逐渐升高。同时,新骨组织中的钙磷比保持在一个较高的水平上,没有太大的变化。新骨从材料周围不断向材料内部渗入,材料被分散、降解,两者的组成成分趋于一致,最终材料被新骨所取代。骨内植入β磷酸三钙多孔陶瓷后不仅材料本身己部分溶解和降解,而且在植入陶瓷的表面和孔隙中以及界面处均己生成新生骨组织,这说明植入无生命的钙磷无机材料后的降解产物参与构成有生命的新生骨组织。Compositions of materials/new bone interface and new bone were investigated by electron probe and X-ray energy spectrum after porous calcium phosphate artificial bone were implanted in the tibia of rabbits. Element changes of the interface, the changes of implanted materials at different stages after implantation and formation of new bone were observed. Results show that the content of carbon element decreases gradually in new bone tissue, while contents of calcium and phosphorus elements increase with implantation time. Meanwhile there are no much differences in the calcium-phosphorus ratio in the new bone and it keeps at a higher level. The new bone grows from outside into inside of the materials, which is dispersed and degraded. The composition of the materials and the new bone tend to consentience. Eventually the materials are replaced by the new bone. After implantation, the new bone formed on the surface, holes and the interface of β-tricalcium phosphate porous bioceramics, besides being dissolved and degraded partially of the materials by themselves. It indicates that degradation products of no life calcium phosphate inorganic materials take part in the formation of the new bone tissue.

关 键 词：多孔磷酸三钙 电子探针 体内植入 组成变化 

分 类 号：R318.08[医药卫生—生物医学工程]