地高辛血药浓度数据处理程序的研制及有效血药浓度范围的调整  

Development of the Data Processing Program of Digoxin and Adjustment of Effective Blood Drug Concentration Range

作　　者：向莉[1] 李盾[1] 

机构地区：[1]暨南大学医学院附属第二医院,深圳市518020

出　　处：《中国药房》2004年第8期485-487,共3页China Pharmacy

基　　金：深圳市科技局基金资助项目(20000617;200204048)

摘　　要：目的 :开发地高辛血药浓度数据处理 (DBDP)程序 ,确定地高辛有效血药浓度范围。方法 :采用VB6 0开发DBDP程序 ,在WIN95操作系统上运行 ;对经荧光偏振免疫法测定的血药浓度数据运用DBDP程序处理。结果 :该程序具有估算药动学参数、建立有效血药浓度范围、管理血药浓度监测数据、自动添加患者档案、多功能模糊查询、回顾性分析等综合功能及临床用药查询等综合功能 ;确定地高辛的理想有效血药浓度范围为0 58～2 01ng/ml。结论 :DBDP程序是开展治疗药物监测工作非常实用的工具。开展血药浓度监测并建立理想的有效血药浓度范围是非常必要的。OBJECTIVE:To develop the data processing program of Digoxin blood drug concentration(DBDP)and to determine the range of effective blood concentration of Digoxin.METHODS:The DBDP program was developed by VISUAL BASIC6.0and run in Windows95system.The data of blood drug concentration,which was determined with flurescence polarization immunoassay(FPIA)in our hospital,was analyzed with DBDP program and effective blood drug concentration range of Digoxin was set up.RESULTS:The DBDP program integrated functions including pharmacokinetic parameter estimation,establishment of the effective blood drug concentration range,management of the data of the blood drug concentration moniˉtoring,automatic addition of patient's file,multifunctional fuzzy searching,retrospective analysis and clinical query about drug use.The effective blood drug concentration range of Digoxin was0.58～2.01ng/ml.CONCLUSION:The DBDP program is a very practical tool for the development of therapeutic drug monitoring and it is very necessary to develop blood drug concenˉtration monitoring and establish the effective blood drug concentration range.

关 键 词：地高辛血药浓度数据处理程序 血药浓度 药动学参数 治疗药物监测 

分 类 号：R311[医药卫生—基础医学] R972.1