高效液相色谱法测定医用消毒洗手液中三氯生的含量  

Determination of Triclosan in healthcare personnel handwash formulations by HPLC

作　　者：洪麟 洪传沪 

机构地区：[1]上海麟翔生物技术有限公司,上海200063

出　　处：《齐鲁药事》2004年第5期31-32,共2页qilu pharmaceutical affairs

摘　　要：目的 介绍一种在医用消毒洗手液中测定三氯生含量的高效液相色谱法。方法 采用HPLC法。结果 采用HPLC法可获得优良的分离效果,对医用消毒洗手液中的三氯生具有高度专一性,定量范围宽(3.0μg·m-l～250.3μg·ml-1),回收率良好(99.79%～100.36%),分析精度高(CV0.19%),最低检测量为0.3μg·ml-1。结论 HPLC可有效地用于产品质量控制,也可用于测定产品的稳定性。Objective To introduce a high performance liquid chromatographic assay which was developed to determine Triclosan concentra-tion in healthcare personnel handwash formulations. Methods Used the method of HPLC. Results The method showed high selectivity toTriclosan in disinfectant product matrix, quantitative range (3.0～250.3μg·ml-1), recovery (99.79～100.36%), analytical precision (CV within 0.19%)and limit of detection (0.3μg·ml-1). Conclusion HPLC can be effectively used to control quality and to test stability of products.

关 键 词：三氯生 高效液相色谱 消毒洗手液 

分 类 号：TQ460.72[医药卫生—药物分析学]