上海市人类免疫缺陷病毒阳性人群HIV-1分布特征分析  

The genetic diversiuy of Human Immunodeficiency Virus type I infections in Shanghai

作　　者：潘启超[1] 康来仪[1] 薛以乐[1] 郑晓虹[1] 金子辰[1] 钟平[1] 

机构地区：[1]上海市疾病预防控制中心,上海200336

出　　处：《上海预防医学》2004年第8期361-364,共4页Shanghai Journal of Preventive Medicine

摘　　要：[目的 ]　分析上海市人类免疫缺陷病毒 (HIV )阳性人群HIV -1分布特征 ,为制定预防HIV传播措施提供科学依据。　 [方法 ]　选择 40例不同感染途径的HIV阳性者 ,提取其血浆中核酸进行扩增 ,然后进行序列测定 ,确定其HIV -1型别。　 [结果 ]　 3 8例分离到核酸的阳性者中 ,发现 4种HIV -1亚型 (A、B、B’和C)、2种重组亚型 (CRF0 1_AE和CRF0 8_BC)和 1种未见报道的亚型 (CRF0 1_AEenvBgagUpol)。不同人群感染毒株不同 ,经性接触传播感染者感染毒株较为广泛 ( 7种 ) ,而经血传播者都为B/B’亚型。　 [结论 ]　上海地区存在着多样的HIVObjective To investigate the genetic diversity of Human Immunodeficiency Virus type I(HIV-1) circulating in Shanghai and to provide scientific evidence for prevention of transmission. [Methods] 40 HIV infections were selected as study subjects. HIV-1 env, gag, pol genes in infected plasma samples were amplified by RT-PCR, sequenced and phylogenetically analyzed. [Results] Four HIV-1 subtype (A, B, B' and C), two circulating recombinant forms (CRFs)(CRF01_AE and CRF08_BC) and one new intersubtype recombinant CRF_01ABU were identified. There were different strains in different target groups. The target group infected through sexual contact had broad strains (7 subtypes) while the target group infected through blood contact only had the same B/B' strains. [Conclusion] The broad HIV-1 diversity exists in Shanghai.

关 键 词：上海市 人类免疫缺陷病毒 阳性人群 HIV-1 分布特征 序列分析 

分 类 号：R512.91[医药卫生—内科学] R373.9[医药卫生—临床医学]