醛固酮合酶基因多态性与原发性高血压及血浆醛固酮水平的关系  

Relationship of aldosterone synthase gene polymorphism with essential hypertension and plasma aldosterone levels

作　　者：王蕊[1] 王晋明[2] 谢忆山[3] 胡晓军[2] 

机构地区：[1]武汉大学人民医院急诊科,武汉430060 [2]武汉大学人民医院心血管内科,武汉430060 [3]武汉大学人民医院肿瘤科,武汉430060

出　　处：《临床内科杂志》2004年第8期524-526,共3页Journal of Clinical Internal Medicine

摘　　要：目的　探索武汉地区汉族人群中醛固酮合酶 (CYP11B2 )基因 3 44C/T多态性与原发性高血压 (EH)的相关性 ,及高血压人群醛固酮合酶CYP11B2基因 3 44C/T多态性与血浆醛固酮(pAldo)水平的相关性。方法　应用PCR RELP技术对 2 0 4例CYP11B2基因 3 44C/T多态性进行分析 ,应用放射免疫法测定 10 6例EH组的血浆醛固酮水平。结果　CYP11B2基因 3 44C/T多态性以TT和CT为主要基因型 ,与EH无明显相关性 (P >0 .0 5 )。高血压患者血浆醛固酮水平在CYP11B2基因 3 44C/T的 3个不同基因型组比较差异有显著性 (P <0 .0 1)。结论　武汉地区汉族人群CYP11B2基因 3 44C/T多态性频率与EH没有明显相关性。高血压人群的血浆醛固酮水平与CYP11B2基因 3Objective To investigate the relationship of gene polymorphism of aldosterone synthase(CYP11B2) gene with essential hypertension(EH) in Chinese population,and the relationship of gene polymorphism of aldosterone synthase (CYP11B2) gene with plasma aldosterone (pAldo) levels in hypertensive patients.Methods Study was conducted using PCR-RELP techniques to explore the relation between aldosterone synthase gene polymorphism and essential hypertension in 204 subjects.The plasma aldosterone (pAldo) levers was measured by radioimmunoassay (RIA) in 106 subjects with EH.Results Both TT and CT were major frequent genotypes.There was no significant association between aldosterone synthase gene polymorphism and EH in the group of 204 Chinese individuals(P>0.05).Significant differences of plasma aldosterone (pAldo)levers are founded among the TT,TC and CC genotypes in EH population(P<0.01).Conclusions No significant association was observed for aldosterone synthase allele status and essential hypertension in Chinese Han population.The plasma aldosterone (pAldo)levers were associated with aldosterone synthase gene polymorphism in Chinese Han people with EH,and the -344C allele was associated with higher(P<0.05) plasma aldosterone levels.

关 键 词：高血压 基因多态性 醛固酮 

分 类 号：R544.1[医药卫生—心血管疾病]