在恒化器模型中对大黄抗龋作用的评估  

The Evaluation of the Anticarious Effects of Radix et Rhizoma Rhei in Chemostat Model

作　　者：肖悦[1] 刘天佳[2] 黄正蔚[2] 周学东[2] 

机构地区：[1]广东省深圳市第二人民医院口腔科,深圳518035 [2]四川大学华西口腔医学院,成都610041

出　　处：《现代临床医学生物工程学杂志》2004年第3期200-202,共3页Journal of Modern Clinical Medical Bioengineering

基　　金：联合利华公司英国研究中心资助项目

摘　　要：目的　在恒化器模型中对大黄的抗龋作用进行评估 ,为研制防龋天然药物新配方提供实验依据 .方法　采用能模拟天然口腔的连续培养型恒化器模型 ,就大黄粗提物对变形链球菌 (以下简称变链 )的生长、产酸及在羟磷灰石表面粘附的影响进行初步评估 .结果　大黄粗提物可明显抑制变链的产酸及对羟磷灰石表面的附着 ,而对液相中的细菌数量无明显影响 .结论　大黄是一种有效的抗龋药物 。Objective To evaluate the anticarious effects of Radix et Rhizoma Rhei through the tests in chemostat caries model, in order to provide experimental evidences for making up natural medicines to prevent caries. Methods The effects of the crude extract of Radix et Rhizoma Rhei on the growth, acidogenicity and attachment on hydroxyapatite(HA)discs were evaluated in continuous culture model. Results In chemostat, Radix et Rhizoma Rhei could inhibit the acidogenicity of Streptococcus mutans and its attachment on HA discs, but had no effect on the amount of bacteria in planktonic phase. Conclusion Radix et Rhizoma Rhei is an effective anticarious natural medicine.

关 键 词：恒化器 连续培养 大黄 变形链球菌 

分 类 号：R285[医药卫生—中药学]