MCI-154对离体大鼠心功能效应的研究  

Effects of MCI-154 on Isolated Heart Function of Rat

作　　者：陈还珍[1] 崔香丽[2] 郭文玲[1] 赵画晨[2] 赵录英[2] 吕吉元[1] 吴博威[2] 

机构地区：[1]山西医科大学第一医院 [2]山西医科大学

出　　处：《中西医结合心脑血管病杂志》2004年第8期467-469,共3页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的　观察钙增敏剂MCI -15 4对正常及高血压心肌肥厚大鼠心功能的效应。方法　采用大鼠离体心脏灌流的方法。结果　①正常及心肌肥厚大鼠的主动收缩压LVDP ,LVEDP无显著性差异 ;②MCI -15 4剂量依赖性的提高了正常及心肌肥厚大鼠的收缩功能 ;③MCI -15 4可轻微改善心脏的舒张功能。结论　MCI -15 4可增强正常及心肌肥厚大鼠的心功能。Objective To study effects of MCI-154 , a calcium sensitizer , on left ventricular ( LV ) contractility and relaxation in normal and hypertrophied hearts.Methods Langendorff-perfusion were used.Results ①No statistical difference was observed between normal and hypertrophied hearts in LVDP and LVEDP;②MCI-154 improved cardiac systolic function in a dose-dependent manner;③MCI-154 slightly improved diastolic function.Conclusion MCI-154 improved heart function of normal and hypertrophied rat.

关 键 词：MCI-154 钙增敏剂 心功能 高血压心肌肥厚大鼠 

分 类 号：R541[医药卫生—心血管疾病]