胰岛素样生长因子1及胰岛素样生长因子结合蛋白3与胎儿宫内生长发育的关系  

Relationship among insulin-like growth factor 1、insulin-like growth factor binding protein 3 and human fetal development

作　　者：洪茜萍[1] 姜丽红[1] 刘戈力[1] 

机构地区：[1]天津医科大学总医院儿科,天津300052

出　　处：《实用儿科临床杂志》2004年第8期645-647,共3页Journal of Applied Clinical Pediatrics

摘　　要：目的　通过测定新生儿脐血中胰岛素样生长因子 1(IGF 1)和胰岛素样生长因子结合蛋白 3(IGF BP 3)水平 ,研究其与出生体质量、身长及胎盘质量等生长参数间的关系 ,探讨影响胎儿宫内生长发育的内分泌因素。方法　将新生儿根据出生体质量与胎龄的关系分为适于胎龄儿 (AGA)组与小于胎龄儿 (SGA)组 ,分别测定两组出生时身长、体质量和胎盘质量 ,同时取新生儿脐血用免疫放射法测定IGF 1和IGFBP 3含量。结果　1) 10 5例新生儿中 79例AGA和 2 6例SGA ,其出生时身长、体质量和胎盘质量 3个参数比较均存在显著差异(P <0 .0 0 1) ,AGA组显著高于SGA组 (P <0 .0 0 1) ;2 )两组脐血IGF 1和IGFBP 3比较 ,AGA组IGF 1和IGF BP 3水平均高于SGA组 (P <0 .0 1和P <0 .0 0 1) ;3)出生时身长、体质量和胎盘重质 3个生长参数均与IGF 1和IGFBP 3呈显著正相关 (P均 <0 .0 0 1)。结论　 1.出生时身长、体质量和胎盘质量可用来评价AGA和SGA的生长发育。 2 .AGA脐血中IGF 1和IGFBP 3明显高于SGA。 3.胎儿自身分泌IGF 1和IGFBP 3与上述生长参数密切相关 ,其对胎儿的生长发育起重要调节作用。IGF 1和IGFBPObjective To study the relationship among insulin-like growth factor 1 (IGF-1), insulin-like growth factor binding protein 3(IGFBP-3) and birth weight, length and placental weight and to discuss the endocrine factors which affected fetal growth by assaying levels of IGF-1、IGFBP-3 in umbilical cord serum.Methods The neonates were divided into appropriate for gestational age infant(AGA) and small for gestational age infant(SGA) according to birth weight and gestation. The birth weight, length and placental weight of neonates were measured and at meantime the levels of IGF-1 and IGFBP-3 were assayed by immunoradiometric assay.Results 1.There were 105 neonates, including 79 AGA and 26 SGA. There were significantly statistical differences in birth weight, length and placental weight (all, P<0.001).The growth parameters of AGA were higher than those of SGA (P<0.001). 2.The levels of IGF-1 and IGFBP-3 in AGA were higher than those of SGA (P<0.01 and P<0.001).3.There was positive correlation among birth weight, length, placental weight and IGF-1 and IGFBP-3 (all, P<0.001).Conclusions 1.Birth weight, length and placental weight can be used to evaluate the growth of human fetus.2.The levels of IGF-1 and IGFBP-3 in AGA are higher than those of SGA.3.IGF-1 and IGFBP-3 of fetal origin are correlated with growth parameters closely,which play an important role in fetal growth, IGF-1 and IGFBP-3 may be the indicators for growth of human fetus.

关 键 词：胰岛素样生长因子1 胰岛素样生长因子结合蛋白3 适于胎龄儿 小于胎龄儿 

分 类 号：R714.5[医药卫生—妇产科学]