颅脑损伤患者血浆D-二聚体含量与伤情及预后的相关性  

Correlation of plasma D-dimer level in patients with head injury to the severity and prognosis

作　　者：黄波[1] 伍爱平[1] 陈冬妹[1] 刘勇[1] 李政[1] 高添喜[1] 黄惠伦[1] 

机构地区：[1]中山市博爱医院,广东中山528403

出　　处：《临床误诊误治》2004年第8期542-543,共2页Clinical Misdiagnosis & Mistherapy

摘　　要：目的探讨D 二聚体含量与颅脑损伤病人伤情及预后的相关性。方法应用免疫比浊法动态检测 90例不同伤情的颅脑损伤病人血浆中D 二聚体的含量 ,并与健康体检者进行对照 ,比较D 二聚体含量与格拉斯哥昏迷分级 (GCS)和格拉斯哥预后分级 (GOS)的关系。结果患者组D 二聚体含量明显高于对照组 ,并与GCS、GOS呈负相关 ,且随伤情演变同步升降。结论动态监测血浆D 二聚体的变化有助于早期准确地判断颅脑损伤伤情与预后。Objective To explore the correlation of plasma D-dimer level with the severity and prognosis of head injury.Methods The plasma levels of D-dimer were dynamically measured with immunoturbidimetry in 90 patients with head injuries and 30 normal controls. And the relationship between Glasgow coma score(GCS),Glasgow outcome score(GOS)and the concentration of D-dimer were also compared.Results The plasma levels of D-dimer in patients with head injuries were increased markedly,compared with those in healthy controls.The concentration of D-dimer correlated negatively with GCS and GOS.This pattern of correlation was changing along with the development of head injury.Conclusions Dynamic detection of D-dimer in plasma might be useful to judging the severity and prognosis of head injury at early stage.

关 键 词：颅脑损伤 D-二聚体 格拉斯哥昏迷量表 格拉斯哥预后评分 

分 类 号：R651.1[医药卫生—外科学]