肝移植4例报告  

Liver transplantation: report of 4 cases

作　　者：马建国[1] 于松宁[1] 王琦[1] 卜阳[1] 王锋[1] 杨银学[1] 

机构地区：[1]宁夏医学院附属医院,宁夏银川750004

出　　处：《宁夏医学杂志》2004年第8期462-464,共3页Ningxia Medical Journal

摘　　要：目的　总结肝移植的临床经验。方法　对 4例男性患者施行肝移植 ,其中 2例为经典式原位肝移植 ,另 2例为背驮式原位肝移植。行肝移植的原因分别为乙肝肝硬化、慢性重肝 (3例 ) ,乙肝活动期、亚急性肝坏死(1例 )。术后免疫抑制剂治疗采用赛尼哌单抗、甲基强的松龙及他克莫司联合用药 ,必要时加用吗替麦考酚酯。同时 ,采用抗乙肝免疫球蛋白 (抗 -HBsIg)及拉米夫定预防乙肝病毒的复发。结果　 4例均获治愈 ,已分别存活 10个月、7个月、2个月和 1个半月。结论　肝移植是治疗良性终末期肝病的有效治疗方法。适应症的选择和手术时机的正确把握 ,围手术期的严密监测。Objective To sum up the clinical experiences of liver transplantation.Methods All recipients were male. The average age was 45 year old(36-49). The indications included terminal liver cirrhosis(2 cases), subacute hepatic failure(1 case), small hepatocellular carcinomas with cirrhosis(1 case). The blood types of recipients and donors were identical. The immunosuppressive protocols included Zenapax and methylpredinisone(MP) and FK506. MMF was added if necessary.Meanwhile intravenous antihepatitisB immunglobulin and Lamivudine were used to preventing hepatitisB recurrence. Of the four patients, the former two operation were standard orthotopic liver transplantation, the latter were the piggyback liver transplantation.Results All patients were cured. The longest survival of 10 months was found in 1 patient. Conclusion Liver transplantation is an effective treatment for benign diseases with terminal liver cirrhosis. Proper indication and optimum operation time ,intensive perioperative supervision proper treatment were very important for improved effect of liver transplantations.

关 键 词：肝移植 肝硬化 免疫抑制剂 

分 类 号：R657.3[医药卫生—外科学]