角质层渗透性质的三维数值模拟  

3D Numerical Simulation of Stratum Corneum Penetration

作　　者：刘宇红[1] Dirk Feuchter Gabriel Wittum 张恩平[1] 曾衍钧[1] 

机构地区：[1]北京工业大学生物力学与医学信息研究所,北京100022 [2]Technical Simulation Group of the Interdisciplinary Cen-ter for Scientific Computing of University Heidelberg

出　　处：《航天医学与医学工程》2004年第4期251-255,共5页Space Medicine & Medical Engineering

基　　金：德国DAAD奖学金资助

摘　　要：目的从数值模拟的角度研究药物渗透皮肤角质层的过程,为实际的药物工作者提供理论上的指导和帮助。方法用有限元方法离散偏微分方程的差分格式,将角质层的角蛋白细胞近似为物理学上经典的由6个四边形和8个六边形围成的三维十四面体结构,同时将角蛋白细胞间的脂质体视为十四面体结构的一部分,离散其相应的单元网格。结果得到了药物渗透皮肤角质层的三维数值模拟,并给出了模拟过程中浓度和速度变化的可视化效果示意图。结论本文所采用的几何模型与实际的生理结构模型非常接近,数值模拟结果证明这一方法对实际工作有参考意义。Objective Using numerical simulation to obtain the parameters in the procedure of drug penetration through skin stratum corneum(SC) to provide help for the researchers in pharmaceutics theoretically. Method Finite element method was used to get the discretization of the partial differential equation. SC cell was treated in 3-dimension as a tetrakaidecahedron with 14-surfaces including six quadrangles and eight hexagons. Lipid layer was regarded as part of the tetrakaidecahedron to finish the discretization of the whole stratum corneum. Result The numerical simulation result was obtained. The visualization in concentration and velocity of the drug at different time points can be showed in figures. Conclusion Compared with in vivo experiments, the geometry model used in this work is quite suitable; the results of the numerical simulation can help the researchers' work in pharmaceutics.

关 键 词：角质层 渗透 十四面体 数值模拟 三维模型 

分 类 号：R318.01[医药卫生—生物医学工程]