上海市健康女性峰值骨量的非遗传因素特征  

Non-genetic features of peak bone mineral density in healthy women of Shanghai

作　　者：秦跃娟[1] 章振林[1] 黄琪仁[1] 周琦[1] 胡云秋[1] 李淼[1] 刘玉娟[1] 

机构地区：[1]上海交通大学附属第六人民医院骨质疏松防治中心,骨质疏松研究室,上海市200233

出　　处：《中国临床康复》2004年第24期5063-5065,共3页Chinese Journal of Clinical Rehabilitation

摘　　要：目的了解上海市健康女性峰值骨密度与非遗传因素的关系,为防治骨质疏松症提供指导依据。方法应用双能X线吸收仪测定433例年龄20～40岁上海市健康汉族女性腰椎1～4和股骨颈、大转子、Ward's三角部位骨密度值,并进行相关因素调查。结果腰椎1～4和股骨近端各部位的骨密度峰值分别出现在30～34岁和20～24岁;各检测部位骨密度值与体质量呈显著正相关(β=0.283～0.373,P<0.001),与月经初潮年龄负相关(β=-0.151～0.093,P<0.05);年龄与大转子、Ward's三角部位骨密度值呈负相关(β=-0.137,-0.194,P<0.05);身高与腰椎1～4骨密度值呈正相关(β=0.152,P<0.05);职业与股骨颈和Ward's三角部位骨密度值相关(β=0.001,0.116,P<0.05)。0～18岁开始摄入牛奶者(A组)与18岁后开始摄入者(B组)比较,年龄、身高和体质量无差异(P>0.05),A组各部位骨密度值显著高于B组(P<0.05)。结论适当体质量、身高、体力劳动和18岁前牛奶摄入有助于获得更高的峰值骨密度,而月经初潮年龄滞后是峰值骨密度的危险因子。AIM:To investigate the relationship between peak bone mineral density(BMD) and non genetic factors in healthy Shanghai women,and to provide instructive evidence for preventing and treating osteoporosis.METHODS:BMD at lumbar spine(L1～4),proximal femur,greater trochanter and Ward's triangle were measured by duel energy X ray absorptiometry in 433 healthy women aged 20-40 years of Han nationality in Shanghai,and relative factors were investigated.RESULTS:The peak BMD was seen in 30-34 years at lumbar spine and 20-24 years at proximal femur respectively.BMD at all measurement sites were positively associated to body mass significantly(β=0.283-0.373,P< 0.05),and negatively associated to menarche age(β=-0.151 to 0.093,P< 0.001).Age was negatively related to BMD at greater trochanter and Ward's triangle(β=-0.137,-0.194,P< 0.05) and height was positively associated to BMD at L1-4(β=0.152,P< 0.05).Profession was also positively related to BMD at neck and Ward's triangle(β=0.001,0.116,P< 0.05). No significant difference in age,height and body mass between women who began to drink milk from 0-18 years(group A) old and after 18 years old(group B,P >0.05).BMD in all site of group A were all higher than that of group B(P< 0.05).CONCLUSION:Appropriate body mass,height,physical activity and milk consumption during childhood and adolescence are benefit in attaining higher peak BMD,and menarche delay is a risk factor for peak BMD.

关 键 词：上海 健康女性 峰值骨量 非遗传因素 骨密度 骨质疏松症 

分 类 号：R681[医药卫生—骨科学]