荞麦叶总黄酮对血脂及脂质过氧化物的作用(英文)  

Effects of total flavones of buckwheat leaf on blood lipid and lipid peroxides

作　　者：朱丽莎[1] 马新超[2] 韩淑英[1] 刘淑梅[1] 吕华[1] 

机构地区：[1]华北煤炭医学院药理学教研室,河北省唐山市063000 [2]华北煤炭医学院物理教研室,河北省唐山市063000

出　　处：《中国临床康复》2004年第24期5178-5179,共2页Chinese Journal of Clinical Rehabilitation

基　　金：Key Program of Tangshan Munieipal Seience and Technology Committee,No.0214613A

摘　　要：背景研究证明荞麦种子有降糖、降脂及抗氧化作用,而有关荞麦叶对脂蛋白失调的影响的研究尚较缺乏。目的研究荞麦叶总黄酮(totalFlavonesofbuckwheatleaf,TFBL)对血脂及脂质过氧化物的影响。设计完全随机对照的实验研究。地点、材料和干预实验在华北煤炭医学院药理学教研室和华北煤炭医学院附属医院同位素科完成。实验选用SD大鼠30只,清洁级,雌雄各半。用高脂饲料诱发大鼠高脂血症,口服TFBL0.3g/(kg·d),干预治疗12周。主要观察指标①TFBL对高脂血症大鼠血脂的影响。②TFBL对高脂血症大鼠血清及肝组织丙二醛和超氧化物歧化酶(superoxidasedismu-tase,SOD)的影响。结果TFBL组高脂血症大鼠血清三酰甘油、载脂蛋白B和低密度脂蛋白胆固醇[(0.49±0.11),(0.04±0.02),(1.78±0.31)mmol/L]明显低于模型组[(0.73±0.15),(0.06±0.02),(2.47±0.13)mmol/L](t=4.080,P<0.01;t=2.401,P<0.05;t=6.491,P<0.01)。TFBL组血和肝组织丙二醛也明显低于模型组(t=3.888,2.667,P<0.05)。同时TFBL还能明显增加血中SOD活力(t=2.765,P<0.05)。结论TFBL具有调血脂和抗脂质过氧化作用。BACKGROUND:Studies have demonstrated that buckwheat seed can lower blood glucose and blood lipid,and resist oxidation.However,studies on the effect of buckwheat leaf on lipid protein imbalance are lacking.OBJECTIVE:To explore the effects of total flavones of buckwheat leaf(TFBL) on blood lipid and lipid peroxides.DESIGN:Completely randomized controlled trial.SETTING,MATERIALS and INTERVENTIONS:The experiment was performed in the Department of Pharmacology,North China Coal Medical College,and the Department of Isotope,the Affiliated Hospital of North China Coal Medical College.A total of 30 SD rats,weighing (220±20) g each,clean degree Ⅱ,half males and half females,were selected.The hyperlipidemia model of rats was induced by high lipid feed and orally treated with TFBL for 12 weeks at the dosage of 0.3 g/(kg per day).MAIN OUTCOME MEASURES:The effect of TFBL on blood lipid of rats with hyperlipidemia,and effect of TFBL on superoxidase dismutase(SOD) and malonaldehyde(MDA) in the serum and liver of rats with hyperlipidemia.RESULTS:Serum triglyceride,apolipoprotein B and low density lipoprotein cholesterol[(0.49±0.11),(0.04±0.02),(1.78±0.31) mmol/L] in TFBL group of hyperlipidemia model rats were significantly lower than those in model group[(0.73±0.15),(0.06±0.02),(2.47±0.13) mmol/L](t=4.080,P< 0.01;t=2.401,P< 0.05;t=6.491,P< 0.01).Compared with that of model group,the malonaldehyde content of serum and liver in TFBL group was notably lowered,too(t=3.888,2.667,P< 0.05). Meanwhile,TFBL could also improve the activity of serum SOD (t=2.765,P< 0.05).CONCLUSION:TFBL has the effect of regulating blood lipid and resisting lipid peroxidation.

关 键 词：荞麦叶 总黄酮 血脂 脂质过氧化物 高脂血症 

分 类 号：R259.892[医药卫生—中西医结合]