缬沙坦联合卡托普利治疗尿毒症顽固性高血压  

Effect of Valsartan Combined with Captopril on Refractory Hyp ertension in Uremia Patients

作　　者：游天禄[1] 何娅妮[2] 游小丽[3] 

机构地区：[1]第三军医大学成都军医学院第47医院内一科,四川成都610500 [2]第三军医大学大坪医院肾内科,重庆400042 [3]成都市新都区人民医院内一科,610500

出　　处：《医药导报》2004年第9期630-632,共3页Herald of Medicine

摘　　要：目的 :探讨治疗尿毒症顽固性高血压的有效方法。方法 :尿毒症顽固性高血压病患者 3 0例 ,随机分为 3组 ,每组 10例 ,分别服用缬沙坦 (缬沙坦组 )、卡托普利缓释片 (卡托普利组 )、缬沙坦 +卡托普利缓释片 (联合组 ) ,实验前3组均服用硝苯地平、美托洛尔。药物剂量分别为 :卡托普利缓释片 3 7.5mg ,qd ;缬沙坦 80mg ,qd ;硝苯地平 10mg ,tid ;美托洛尔 5 0mg ,tid。比较各组治疗前及治疗 4周后早晨 6时血压、血浆内皮素水平以及超声心动图的变化。结果 :3组治疗 4周后早晨 6时血压、血浆内皮素水平、舒张晚期最大血流速度和舒张早期最大血流速度比值 (A E值 )较治疗前均有显著下降 (P <0 .0 1) ,其中联合组较卡托普利组和缬沙坦组更显著 (P <0 .0 1)。结论 :缬沙坦、卡托普利缓释片是治疗高血压的有效药物 ,二者联合应用是治疗尿毒症顽固性高血压的较好方法。Objective:To study effect of valsartan combine d with captopril on refractory hypertension in uremia patients. Methods:Thirty suitable patients were evenly randomised into three groups: Group A received valsartan and captopril of sustained-releas e tablets, group B only valsartan; and group C captopril of sustained-release t ablets. All three group took nifedipine and betaloc before the treatment. The do ses of the drugs is separately: captopril sustained-release tablets, 37.5 mg qd , valsartan, 80 mg qd; nifedipine 10 mg tid, betaloc 50 mg tid. The changes of b lood pressure, the plasma ET-1 at 6 AM, and the echocadiagram among three group s before treatment and 4 weeks after the treatment. Results:Blood pressure and the plasma ET-1 at 6 AM and E/A of three groups decreased significantly after the treatment(P<0.01). Th e decrease of blood pressure, the plasma ET-1 at 6 AM and E/A in group A was si gnificantly different from that in group B and in group C(P<0.01). Conclusion:Both captopril sustained-release tablets and valsartan are effective, and the combining use of the two drugs is effective on refractory hypertension in uremia patients.

关 键 词：缬沙坦 卡托普利 高血压 顽固性 尿毒症 

分 类 号：R972.4[医药卫生—药品] R544.1[医药卫生—药学]