肝脏隔离灌注中活性炭用量对表柔比星吸附效果的影响  

Effect of Activated Carbon on Adsorbing Epirubicin in Isolated Hepatic Perfusion

作　　者：向莉[1] 李盾 

机构地区：[1]暨南大学医学院第二附属医院药学部 [2]深圳市人民医院药学部,518020

出　　处：《医药导报》2004年第9期679-681,共3页Herald of Medicine

摘　　要：目的 :研究在肝脏隔离灌注治疗肝癌过程中 ,活性炭作为表柔比星吸附剂的最佳用量。方法 :采用含表柔比星的血浆灌注于不同组合量的活性炭罐 ,A组 ( 15 0g× 1) ,B组 ( 15 0g× 2 ) ,C组 ( 15 0g× 3 ) ,D组 ( 15 0g× 4) ,E组 ( 15 0g× 5 )及F组 ( 15 0g× 6) ,用高效液相色谱柱切换法测定表柔比星过滤前后血药浓度。结果 :A、B、C、D、E、F组活性炭对表柔比星的吸附率分别为 ( 2 5 .60± 4.72 ) % ,( 3 8.47± 4.0 2 ) % ,( 5 0 .13± 2 .68) % ,( 70 .2 5± 2 .17) % ,( 72 .0 2± 2 .2 1) % ,( 73 .90± 4.0 2 ) % ,经两两比较的q检验 ,A、B、C、D任意两组间均差异有极显著性 (P <0 .0 1) ,而D、E、F任意两组间均差异无显著性 (P >0 .0 5 )。结论 :D组活性炭为活性炭吸附剂的最佳用量 ,该用量的确定为肝脏隔离灌注治疗肝癌提供了理论依据。Objective:Study on the dosage of activated car bon as the absorbent of epirubicin (EPI) in isolated hepatic chemoperfusion. Method:The plasma epirubicin was perfused in the activat ed carbon columns with different combination. The plasma epirubicin was determin ed by column switching HPLC. Results:The absorption ratio of epirubicin by A group (1 50 g×1), B group (150 g×2), C group (150 g×3), D group (150 g×4), E group (1 50 g×5), and F group (150 g×6) activated carbon columns respectively were (25. 60±4.72)%,(38.47±4.02)%,(50.13±2.68)%,(70.25±2.17)%,(72.02±2.21)%,(73. 90± 4.02)% . There was a significant difference between any two groups of A, B, C, D by q test (P<0.01). And there was no significant difference between any two groups of D, E, and F(P>0.05). Conclusion:The suitable dosage of activated carbon is gr oup D which provides a theoretical dose in the therapy of liver cancer by isolat ed hepatic perfusion.

关 键 词：表柔比星 肝脏隔离灌注 柱切换 高效液相色谱法 

分 类 号：R978.1[医药卫生—药品] R962.2[医药卫生—药学]