肾素-血管紧张素系统在雄性生殖中的意义  

The Role of the Renin-Angiotensin System in Male Reproduction

作　　者：贾悦[1] 崔毓桂[2] 狄福松[1] 王兴海[3] 

机构地区：[1]南京医科大学第一附属医院内分泌科,江苏南京210036 [2]南京医科大学第一附属医院中心实验室,江苏南京210036 [3]江苏省计划生育研究所,江苏南京210029

出　　处：《中华男科学杂志》2004年第8期623-626,共4页National Journal of Andrology

摘　　要：除血循环外其他组织也存在一些局部肾素 血管紧张素系统 (RAS)调节机制。雄性生殖系统包括睾丸、附睾和前列腺等都有局部RAS的表达。局部RAS对相应部位功能具有调节作用 ,而其本身也受到性激素、脂肪酸、缺氧和药物的影响。研究发现局部RAS不仅与雄性生殖功能有关 ,与前列腺增生也有关系。除此之外 。The circulating renin angiotensin system (RAS) is well known for its role in the maintenance of blood pressure and electrolyte and fluid homeostasis. However, other local angiotensin generating systems than the circulating RAS have been found in numerous tissues. The male reproductive system including the testis, epididymis, and prostate has several sites of intrinsic RAS activity. The local RAS in these tissues can be responsive to androgens, fat acid, drugs, and hypoxia. There has been evidence for the involvement of the RAS not only in male reproduction, but also in the development of prostate disease. Besides, the assessment of the local RAS activity may be helpful to the early diagnosis of tumor in the male reproductive system.

关 键 词：肾素-血管紧张素系统 睾丸 附睾 前列腺 生殖系统肿瘤 男性 

分 类 号：Q42[生物学—神经生物学]