听觉诱发电位指数指导异丙酚靶控麻醉的可行性研究  

Feasibility of application of auditory evoked potential index in guiding target-controlled infusion of propofol

作　　者：陈杰[1] 汪玉林[1] 陶国才[1] 

机构地区：[1]第三军医大学西南医院手术麻醉科,重庆400038

出　　处：《第三军医大学学报》2004年第16期1479-1481,共3页Journal of Third Military Medical University

摘　　要：目的　评价听觉诱发电位指数 (auditoryevokedpotentialindex ,AEP index)指导靶控输注异丙酚维持麻醉的可行性。方法　 16例择期手术病人 ,按随机对数表法随机分为对照组和听觉诱发电位 (auditoryevokedpotential ,AEP)指导组 ,每组 8例。对照组仅凭临床经验来调节异丙酚的靶浓度值。AEP指导组则通过维持AEP index值于 15～ 3 0左右来调节异丙酚的靶浓度值。记录麻醉期间血流动力学及AEP index的变化 ,及两组各麻醉药的用量。结果　①两组血流动力学的变化无显著差异 (P >0 .0 5 )。②麻醉深度监测 ,AEP指导组AEP index值明显高于对照组 (P <0 .0 5 )。③AEP指导组异丙酚的实际用量明显少于对照组 (P <0 .0 5 )。④AEP index能够前瞻性的预测麻醉的减浅。结论　AEP index通过为麻醉深度监测提供量化指标 ,可有效用于异丙酚靶控输注 (targetcontorlledinfusion ,TCI)Objective To assess the feasibility of application of auditory evoked potential (AEP) index to guide target controlled infusion (TCI) of propofol. Methods Sixteen ASAⅠ-Ⅱ patients were randomly divided into ( n =8) control and AEP index ( n =8, for each). Anesthesia was maintained with TCI of propofol. In the control group, the anesthesiologists were blind to the AEP index value, and the concentration of plasma of propofol was administered according to the clinical experience. In AEP index group, the anesthetics was titrated to maintain the AEP index value between 15 to 30. Results ① There was no significant difference in hemodynamic responses in the two groups ( P >0.05). ② The depth of anesthesia: the value of AEP index in AEP index group was significantly higher than that in control group ( P <0.05). ③ The total dosage of propofol in AEP index group was significantly lower than that in the control group ( P <0.05). ④ The value of AEP index could be used to predict the depth of anesthesia. Conclusion AEP index monitoring is valuable in assessment of anesthetic depth during anesthesia with TCI of propofol.

关 键 词：诱发电位 听觉 异丙酚 靶控输注 

分 类 号：R338.3[医药卫生—人体生理学] R614[医药卫生—基础医学]