HPV16 E7多肽冲击的树突状细胞治疗尖锐湿疣的临床初步观察  

Clinical study of the therapy of condyloma acuminate by HPV16 E7 peptide-pulsed dendritic cells

作　　者：黄伟峰[1] 郝飞[1] 刁庆春[1] 钟白玉[1] 

机构地区：[1]第三军医大学西南医院皮肤科,重庆市皮肤性病研究所重庆400038

出　　处：《第三军医大学学报》2004年第15期1388-1390,共3页Journal of Third Military Medical University

基　　金：国家自然科学基金资助项目 ( 30 0 70 6 98)~~

摘　　要：目的　观察人乳头瘤病毒 16型 (HPV16)E749 5 7多肽冲击的树突状细胞 (DCs)治疗复发性尖锐湿疣的疗效。方法　 3 2例复发 3次以上的尖锐湿疣患者 ,治疗组 11例 (HPV16+ 、HLA A2 + )给予HPV16E7多肽冲击的树突状细胞免疫治疗 ,对照组 2 1例给予干扰素治疗。所有患者随访 6个月 ,观察治疗前后皮损的病理变化、外周血T淋巴细胞亚群的变化及治疗效果。结果　抗原肽冲击的树突状细胞治疗后 ,部分尖锐湿疣皮损变小或消退 ,局部空泡细胞减少 ,真皮内有中等密度淋巴细胞浸润。治疗前后外周血T淋巴细胞亚群未见明显变化。复发率由常规治疗的 61.9%降至 18.2 %。结论　运用抗原肽冲击的树突状细胞对复发性尖锐湿疣进行治疗 ,可以改善病变局部的免疫状态 。Objective To investigate the therapeutic efficacy of HPV16 E7 peptide pulsed dendritic cells (DCs) in recurrent condyloma acuminate (CA). Methods A total of 32 cases of recurrent CA (more than 3 times) were divided into the treatment group and the control group. Patients (11 cases, HPV16 +and HLA A2 +) in the treatment group received treatment with DCs, while the other 21 cases in the control group were treated with interferon. A follow up of 6 months was conducted in all patients. The pathological lesions, the peripheral T cell subpopulations of the patients, and the therapeutic efficacy before and after treatment were observed. Results The size of the lesions became smaller or disappeared in the treatment group. The infiltrated lymphocytes increased, but the koilocytotic cells decreased in the lesions. No significant change in the peripheral T cell subpopulations was found before and after therapy. The recurrence rates in the treatment group and the control group were 18.2% and 61.9%, respectively. Conclusion The therapy by E7 peptide pulsed dendritic cells can improve the local immune status in the skin and reduce the recurrence rate significantly in patients with recurrent CA.

关 键 词：乳头状瘤病毒 人 树突状细胞 尖锐湿疣 

分 类 号：R392.11[医药卫生—免疫学] R457.2[医药卫生—基础医学]