止血气雾剂对动脉破裂伤口的止血研究  

Hemostatic aerosol for emergent management of artery rupture

作　　者：孙鸿涛[1] 裴国献[1] 王运斗[1] 张洪涛[1] 张敬良[1] 

机构地区：[1]第一军医大学南方医院全军创伤骨科中心,广东广州510515

出　　处：《第一军医大学学报》2004年第8期910-912,916,共4页Journal of First Military Medical University

基　　金：全军医学科研"十五"计划重点课题(02Z001)~~

摘　　要：目的观测并评价止血气雾剂对肢体动脉破裂伤口的止血效果。方法剪断30头猪的共30条股动脉,按照向伤口喷洒止血气雾剂前是否辅助其他止血方法分为指压止血+止血气雾剂、止血带止血+止血气雾剂和单纯喷止血气雾剂止血这3种方法制作动脉破裂止血模型,每种模型均制作10个,术后12h内观察止血效果。结果止血带组的止血成功率为90%,指压法组的止血成功率30%,单纯喷止血气雾剂的止血成功率为10%。结论对于肢体动脉破裂伤口,采用先扎止血带暂时止血,之后喷洒止血气雾剂,10min后放松止血带的止血方法成功率最高,是首选的止血方法。Objective To investigate the effect of the hemostatic aerosol (HA) for emergent management of artery rupture in pigs. Methods Thirty pigs were used to establish animal models of complete femoral artery rupture by cutting off the arteries. The pigs were divided equally into 3 groups according to the hemostatic measures taken before the application of HA, namely HA spray alone, temporary hemostasis by compressing the wound with fingers, or tourniquet in another group, before HA sprays. In the late groups the finger compression or tournigut was removed 10 min after HA spray. The main indexes including average arterial blood pressure (AABP), times of spray, hemostatic time, time for membrane formation and the thickness of the HA membrane shaped while spraying , and the success rates of each method, were assessed 12 h postoperatively. Results The rate of successful hemostasis achieved by tourniquet and HA spray was 90%, 30% by finger compression and HA spray, and only 10% by direct HA spray. Conclusions For complete artery rupture, application of tourniquet for temporary hemostasis 10 min before HA spay can be the best choice for emergent management of artery rupture.

关 键 词：战伤 动脉破裂 止血 气雾剂 伊拉克战争 猪 

分 类 号：R96[医药卫生—药理学]