电化学治疗肿瘤过程中组织的电导率变化与损伤程度的关系  

Relationship Between the Conductivity Changes and the Deterioration of the Tissues During Electrochemical Treatment

作　　者：原红梅[1] 俞叶锋[1] 陈剑[1] 查全性[1] 熊永炎[2] 林丛尧[2] 郭广松[2] 

机构地区：[1]武汉大学化学与分子科学学院,湖北武汉430072 [2]武汉大学中南医院,湖北武汉430071

出　　处：《武汉大学学报（理学版）》2004年第4期427-430,共4页Journal of Wuhan University:Natural Science Edition

基　　金：武汉大学科技创新基金资助项目(203270017)

摘　　要：研究了电化学处理过程中组织的电导率变化与其损伤程度之间的关系.实验采用恒定直流电流(15mA)电解动物组织及人体恶性肿瘤组织,同时测量电化学处理过程中电导率的变化,然后观察组织的病理切片.结果显示正常组织和恶性肿瘤组织的电导率在电化学处理过程中呈规律性变化,并且与受损组织的病理变化有一定程度的关联.这表明可以用电导率的变化来表征电化学治疗过程中肿瘤组织的损伤程度.The relationship between the conductivity changes and the deterioration of tissues during electrochemical treatment was studied with the aim of finding some parameter that can be used to characterize the degree of deterioration of the tissues during treatment. The pork liver and the human cancer tissue were treated with constant direct current. The changes of the conductivity were measured during electrochemical treatment. The morphological changes of the cells after treatment were investigated under optical microscope. Parallel changes were observed between the conductivity and the degree of deterioration of tissues. Therefore, the degree of deterioration of the tissue probably could be monitored by measuring the conductivity changes during the electrochemical treatment. Experimental results obtained in this work can also be helpful in the optimization of the design of distribution of electrodes (cathodes and anodes) employed in electrochemical treatment.

关 键 词：电化学治疗肿瘤 电导率 肿瘤 

分 类 号：O646.51[理学—物理化学]