功能型二元酸的制备  

Synthesis of Novel Functional Diacids

作　　者：张志琴[1] 苏新梅 白毓[1] 赵保敏[1] 李蔚[1] 曲凡歧[1] 

机构地区：[1]武汉大学化学与分子科学学院,湖北武汉430072 [2]新乡师范专科学校化学系,河南新乡453000

出　　处：《武汉大学学报（理学版）》2004年第4期463-466,共4页Journal of Wuhan University:Natural Science Edition

基　　金：国家重点基础研究发展规划项目资助(G1999064703)

摘　　要：以四氢呋喃作溶剂,用具有生物相容性的己二酸酐分别与甘氨酸、L 丙氨酸以及邻羟基苯甲酸反应,一步合成了3种功能型二元酸:5 羧甲基氨基甲酰戊酸、5 (1 羧乙基)氨基甲酰戊酸、己二酸单(2 羧苯酚)酯.对反应中间体和目标化合物进行红外(IR)光谱、核磁共振氢谱(1HNMR)表征,证实了它们的结构和组成.同时探讨了反应溶剂及反应时间对产物合成的影响.5-(Carboxymethyl-carbamoyl)-pentanoic acid, 5-(1\|carboxy-ethylcarbamoyl)-pentanoic acid and hexanedioic acid mono-(2-carboxy-phenyl) ester were synthesized by reacting adipic anhydride with glycine, L\|alanine and o-hydroxy benzoic acid respectively, using anhydrous THF as solvent. The intermediate and objective products were identified by spectrum of IR,^(1)H NMR. The influence of solvent and reaction time had been studied.

关 键 词：5-羧甲基氨基甲酰戊酸 5-(1-羧乙基)氨基甲酰戊酸 己二酸单(2-羧苯酚)酯 合成 单体 

分 类 号：O631[理学—高分子化学]