三氧化二砷与肿瘤细胞凋亡机制的研究进展  

Reserarch advance on mechanism of arsenic trioxide on tumor

作　　者：郭莉霞[1] 王远亮[1] 辛娟[1] 

机构地区：[1]重庆大学生物工程学院生物力学与组织工程教育部重点实验室,重庆400030

出　　处：《重庆大学学报（自然科学版）》2004年第8期47-51,共5页Journal of Chongqing University

基　　金：国家自然科学基金资助项目(3027039;19872080);教育部基金资助项目

摘　　要：综述了细胞凋亡的相关概念及其三氧化二砷(As2O3)诱导凋亡可能机制的研究进展。查阅近几年国内外有关的文献资料,进行分析、整理和归纳得出,细胞凋亡是细胞与生俱来的一种机制,是最常见的细胞生理性死亡形式,它的异常在肿瘤的发病上具有重要作用。三氧化二砷能够诱导多种肿瘤细胞凋亡,现已用于治疗血液系统肿瘤和实体瘤。其诱导凋亡的机制正在逐渐成为研究的热点,但还远未被研究透彻,随着研究的不断深入,相信不久的将来三氧化二砷很可能为研究肿瘤治疗新策略提供参考。The article demonstrates the relative concepts of apoptosis and summarizes the effect of arsenic trioxide to the carcinoma, its possible principle included. Recent development of the reports about arsenic trioxide-induced apoptosis is referred and reviewed. Apoptosis is a natural mechanism and a common physiological death of cell, and its abnormity has great effect on cancer. Arsenic trioxide can induce apoptosis in APL cell and other cancer cells, and has been used in treating the patient with other kinds of malignant cancers. The mechanisms of arsenic trioxide-induced apoptosis are gradually becoming a hotspot, but still not lucid. With intensive study of arsenic trioxide, it can be a useful ways in treating cancer patients in the future.

关 键 词：三氧化二砷 肿瘤 凋亡 作用机制 

分 类 号：Q255[生物学—细胞生物学]