脱氧氟尿苷针剂对小鼠移植性肿瘤的抑制作用  

The antitumor activity of doxifluridine injection

作　　者：李文钧[1] 马张英[2] 彭小英[1] 屠凌岚[1] 颜冬梅[1] 郑永兴[1] 

机构地区：[1]浙江省医学科学院药物研究所,浙江杭州310013 [2]浙江大学医学院附属邵逸夫医院,浙江杭州310016

出　　处：《中国现代应用药学》2004年第4期271-274,共4页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的　观察脱氧氟尿苷DFUR针剂对动物移植性肿瘤的实验治疗作用。方法　选用肉瘤S180、肝癌HepS、白血病L6 15和艾氏腹水癌ECA等四株小鼠移植性肿瘤 ,观察注射途径下脱氧氟尿苷DFUR的抗肿瘤作用。结果　腹腔、静脉或口服给药 ,DFUR对S180的抑瘤率均大于 80 %。腹腔给药对HepS的抑瘤率为 78% ,对L6 15和ECA的生命延长率为 5 15 %和2 0 2 %。腹腔给药对S180的化疗指数分别为DFUR2 .8,FU1.3,FT2 0 71.4和FUDR1.5。结论　无论是静脉、腹腔或口服给药 ,脱氧氟尿苷DFUR对多种小鼠肿瘤均有明显的抑制作用。与FU ,FT2 0 7和FUDR相比 。OBJECTIVE To evaluate the antitumor activity of doxifluridine(DFUR) injection. METHOD Observation the antitumor effects of doxifluridine by ip, iv or po administration on murine sarcoma S180, ip DFUR on hepatoma HepS, leukemia L615 and Ehrlich Cancer ECA, and comparing the activity of ip DFUR with FU, FT207 and 2’-FUdR on S180 in vivo.RESULTS The growth inhibitory rates of ip, iv and po DFUR to S180 were over 80%, the activity of iv FU to S180 was 45%. The growth inhibition of ip DFUR and FU were 78.5% and 67.1% to HepS; the percent increase in lifespan of ip DFUR and FU were 515.9% and 230.2% to L615; 202.0% and 143.7% to ECA. The therapeutic index to S180 were DFUR 2.8, FU 1.3, FT207 1.4 and FUDR 1.5, respectively.CONCLUSION Doxifluridine administered by ip, iv or po shows the growth inhibitory activity to murine tumor models in vivo with much higher therapeutic index than that of FU, FT207 and FUDR.

关 键 词：抗癌药 脱氧氟尿苷 氟尿嘧啶 

分 类 号：R979.1[医药卫生—药品] R965[医药卫生—药学]