阿西美辛脂质体凝胶剂的研制  

Study on a kind of acemetacin liposome hydrogel

作　　者：李冬梅[1] 路绪文[1] 苏芳 

机构地区：[1]解放军第251医院药材科,河北张家口075000 [2]解放军白求恩军医学院

出　　处：《中国现代应用药学》2004年第4期290-292,共3页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的　研制阿西美辛脂质体凝胶剂 ,并进行评价。方法　采用不同方法、不同药 脂比处方制备脂质体 ,然后对其包封率进行比较 ,从而优选出最佳制备方法与最佳处方 ,并进一步制备成脂质体凝胶剂 ;采用HPLC测定制剂中阿西美辛的含量 ,葡聚糖凝胶柱结合HPLC测定制剂中阿西美辛的包封率 ;考察了制剂的皮肤刺激性与初步稳定性。结果　制剂的含量控制在 0 .0 9%～0 .110 %范围之内 ;平均包封率为 (5 8.76± 12 .4 7) % ;无皮肤刺激性 ;不易高温贮存 ,对光不稳定。结论　经初步评价 ,所制备的阿西美辛脂质体制备方法可行、简便。OBJECTIVE To prepare and evaluate a liposome hydrogel acemetacin(ACM) . METHOD Acemetacin liposome hydrogel was prepared by different method and different prescriptions, the best method and prescription was screened out by comparison the entrapment efficiency. The content and entrapment efficiency of ACM were determined by HPLC and sepharose X-100 combining HPLC, respectively. The stability and dermal irritation were also studied.RESULTS The content of ACM in its preparation was in the range of 0.09%～0.110%(w/w); the average encapsulated efficiency of ACM was58.76±12.47%; the preparation has no effect of skin irritation and unstable in the light and high temperature. CONCLUSION By primary study the acemetacin liposome hydrogel is feasible.

关 键 词：阿西美辛 脂质体 凝胶剂 质量控制 

分 类 号：R976[医药卫生—药品] R944.15[医药卫生—药学]