米索前列醇对产妇血清雌二醇和孕酮水平的影响  

Effect of Misoprostol on serum estradiol and progesterone concentrations in the parturients

作　　者：周玉玲[1] 李罗珍[1] 姜海燕[1] 王雷[1] 王玉华[1] 韩文红[1] 

机构地区：[1]解放军252医院妇产科,河北保定071000

出　　处：《华北国防医药》2004年第4期234-236,共3页Medical Journal of Beijing Military Region

摘　　要：目的 :探讨米索前列醇 (简称米索 )用于足月妊娠引产对产妇血清雌二醇 (E2 )和孕酮 (P)水平的影响。方法 :将 10 6例足月妊娠初产妇随机分为两组 ,分别以米索 5 0 μg、2 5 μg放置于阴道后穹隆 ,每 3小时 1次 ,直至有效宫缩停药 ,每日用药以 4次为限。选择同期住院、自然临产的初产妇 5 6例作为对照组。用放射免疫法测定 3组中部分产妇不同时期血清中E2 和P水平。结果 :① 3组产妇用药、临产后血清E2 水平逐渐升高 ,至第 2产程达高峰 ,胎盘娩出后半小时迅速下降 ,明显低于用药前或临产前水平。②P水平的变化趋势与E2 相反 ,即随着产程进展逐渐下降 ,至胎盘娩出后降至最低水平。③ 3组E2 /P比值于用药、临产后的变化趋势与E2 相似 ,但胎盘娩出后仍明显高于临产前水平 ,与潜伏期水平相当。④对照组临产前孕妇血浆E2 水平及E2 /P值高于两实验组 ,差异显著 (P <0 0 5 ) ,P水平低于实验组 ,但无显著差异 (P >0 0 5 )。至产程中及产后 ,3组同期E2 、P水平及E2 /P值比较无明显差异(P >0 0 5 )。结论 :产妇血浆E2 水平及E2 /P比值的升高与分娩的发动密切相关。米索用于足月妊娠引产 ,可通过改变产妇血浆E2 和P水平影响产程进展 ,其变化幅度与用药剂量一致 ,且变化规律与正常生理性分娩过程相似。Objective:To explore the effects of Misoprostol on serum estradiol (E_2) and progesterone (P) concentrations in the parturients on induced labor for full term pregnancy.Methods:106 primiparas on full term pregnancy were divided randomly into two groups,56 subjects into 50 μg Misoprostol group and the other 50 subjects into 25 μg Misoprostol group respectively. Misoprostol 50 μg and 25 μg were put into posterior fornix once every 3 hours,but no more than 4 times a day,till effective uterine contraction appeared.56 primiparas hospitalized in the same period of time for normal labor served as controls.RIA was applied to measure serum concentrations of E_2 and P at different labor stages.Results: ①For all subjects in the three groups,the levels of E_2 were gradually increased with the development of labor and they reached the highest points at the second stage of labor,but decreased rapidly 30 minutes after the delivery of placenta,even much lower than those before administration of the drug or those of ante partum;② the changes in P levels were shown to have a opposite pattern,being gradually decreased with the development of labor and getting to the lowest level after placenta delivery in all the three groups;③the ratio of E_2/P was similar to the change in concentration of E_2,being still higher than that of ante partum and equivalent to that in latent period;④ E_2 level before labor onset in controls was higher than that of the pre-administration period in the two study groups ( P <0.05);P level was lower than those in the study groups without significant difference ( P >0.05).During the birth process and puerperium,E_2,P and the ratio of E_2 to P were not significantly different from each other among the three groups at the same stage of birth ( P >0.05).Conclusions:The increases of serum E_2 and E_2/P ratio in parturients were closely associated with the labor onset. Misoprostol could influence progress of labor by altering levels of E_2 and P.Their range was in accordance with dosage of t

关 键 词：米索前列醇 引产 雌二醇 孕酮 

分 类 号：R719.31[医药卫生—妇产科学]