糖尿病肾病患者C—反应蛋白与肾功能减退的关系  

Serum C-reactive protein level correlates with renal function damage in patients with diabetic nephropathy

作　　者：尉冬英[1] 郑强[1] 李雪梅[1] 夏映萍[1] 

机构地区：[1]四川省成都市第六人民医院肾内科,四川成都610051

出　　处：《遵义医学院学报》2004年第3期228-229,共2页Journal of Zunyi Medical University

摘　　要：目的　研究糖尿病肾病 (Diabeticnephropathy ,DN)患者C反应蛋白 (C reactiveprotein ,CRP)的稳定性与肾功能减退之间的关系。方法　选择我院住院及门诊治疗的糖尿病肾病 (Ⅲ期 ,Ⅳ期 )患者 5 8例 ,血糖控制稳定 ,排除活动性风湿性疾病、肿瘤及可能影响血清CRP的药物 (非类固醇消炎药、血管紧张素转换酶抑制剂、他汀类降脂药等 )。记录患者性别、年龄、血压、血糖、血肌肝、尿素氮、CRP、双肾ECT、尿白蛋白 / 2 4h、尿蛋白 / 2 4h。 1a后重复测定。结果　两次CRP测定呈显著相关性 (P <0 .0 1) ,且有上升趋势。CRP升高组患者持续处于较高水平 ,其肾功能减退比例明显高于CRP正常组。结论　DN患者持续存在不同强度的慢性炎症状态 。Objective To investigate serum C reactive protein level and its correlation with renal function damage in patients with diabetic nephropathy. Methods This study included 58 patients who were followed up for more than 12 months in our hospital. The effects of active rheumatic disease, neoplasm and drugs (non steroid anti inflammation drugs, angiotensin converting enzyme inhibitors, statins) were ruled out. Sex'age, blood pressure, were recorded. Serum were sampled for the determination of blood sugar, Scr、Bun、CRP assay. Patients sumples of microalbuminuria/24h、proteinuria/24h、Tm99 ECT. were determined. This item were determined repeated agaig after 1 year. Results Good correlation exists between 2 serial CRP measurement (P<0.01), and serum CRP level tended to increase after 1years follow up. Patients in elevated serum CRP group had higher incidence of rend function damage as compared with patients in normal CRP group. Conclusions Persistent inflammation state might be responsible for the elevation of serum CRP level in patients with diabetic nephropathy. Serum CRP level is correlative with renal function damage.

关 键 词：糖尿病肾病 C反应蛋白 肾功能减退 

分 类 号：R587[医药卫生—内分泌]