黄芪甲苷在兔体内的药动学和在大鼠的排泄(英文)  

Pharmacokinetics of astragaloside Ⅳ in rabbits and its excretion in rats

作　　者：马越鸣[1] 谢华[1] 朱世敏[1] 吴耀平[1] 吴大正[2] 胡之璧[2] 

机构地区：[1]上海中医药大学中药学院,上海201203 [2]上海中医药大学中药研究所,上海201203

出　　处：《中国新药与临床杂志》2004年第9期563-567,共5页Chinese Journal of New Drugs and Clinical Remedies

基　　金：上海市科委基金资助 (994 3192 2 5 12 )~~

摘　　要：目的 :研究黄芪甲苷在家兔体内的药动学和在大鼠的排泄。方法 :健康家兔和大鼠一次静脉注射 (静注 )给予黄芪甲苷 4mg·kg- 1,高效液相色谱 蒸发光散射检测器法检测兔血浆和大鼠尿及粪黄芪甲苷浓度 ,用 3P97药动学软件对兔血浆浓度 时间数据进行动力学分析和计算药动学参数 ,并估算大鼠体内的排泄情况。结果 :黄芪甲苷静注给药后 ,T12 α 为 0 .10h ,T12 β 为 1.4h ,Vc 为 0 .15L·kg- 1,VD 为 0 .6L·kg- 1,Cl为 0 .32L·h- 1·kg- 1,AUC为 15mg·L- 1·h。大鼠静注给药后 ,原形从尿和粪排出量分别为给药量的 16 %和 3.2 %。结论 :家兔体内黄芪甲苷的动力学过程符合二室模型 ,大鼠仅有少量原形药物从尿和粪排泄。AIM: To study the pharmacokinetics of astragaloside Ⅳ in rabbits and its excretion in rats. METHODS: Normal rabbits and rats were given a single intravenous dose of astragaloside Ⅳ 4 mg·kg -1. Astragaloside Ⅳ concentrations in the plasma of rabbits and those in the urine and feces of rats were measured by HPLC-ELSD. Pharmacokinetic parameters were determined from the plasma concentration - time data in rabbits with the 3P97 software package and the excretion in rats was estimated. RESULTS: After intravenous administration of astragaloside Ⅳ in rabbits the T__ 12α was 0.10 h, the T__ 12β was 1.4 h, the V_c was 0.15 L·kg -1, the V_D was 0.6 L·kg -1, the Cl was 0.32 L·h -1·kg -1, and the AUC was 15 mg·L -1·h. The excreted amount of astragaloside Ⅳ from urine and feces in rats after intravenous administration was 16 % and 3.2 % of the dose, respectively. CONCLUSION: The kinetic process of astragaloside Ⅳ in rabbits is best fitted to a two-compartmental model. In rats, only small amount of astragaloside Ⅳ was excreted from urine and feces unchanged.

关 键 词：黄芪属植物 药动学 兔 大鼠 黄芪甲苷 排泄 

分 类 号：R286[医药卫生—中药学] R969.1[医药卫生—中医学]