加替沙星与左氧氟沙星治疗泌尿道感染的疗效比较  

Gatifloxacin vs levofloxacin in treatment of urinary tract infections

作　　者：张磊[1] 刘希会[1] 彭涛[1] 于迎[1] 胡昭[1] 

机构地区：[1]山东大学齐鲁医院肾内科,山东济南250012

出　　处：《中国新药与临床杂志》2004年第9期611-613,共3页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :比较加替沙星与左氧氟沙星治疗敏感性细菌引起的泌尿道感染的疗效及安全性。方法 :以左氧氟沙星为对照 ,在 4 8名受试者中进行了随机双盲、双模拟、平行对照试验。A组 2 4例 ,每日给予加替沙星 4 0 0mg口服 ,B组 2 4例 ,每日给予左氧氟沙星 4 0 0mg口服 ,疗程 7～ 14d。结果 :A组病人用药后临床痊愈率为 10 0 % ,有效率为 10 0 % ,B组的痊愈率为 92 % ,有效率为 92 %。 2组间疗效比较 ,差异无显著意义 (P >0 .0 5 ) ;A组和B组的细菌清除率均为 10 0 % ,P >0 .0 5 ;2组不良反应发生率分别为 8%和 12 % ,P >0 .0 5。结论 :加替沙星治疗泌尿道感染疗效及安全性与左氧氟沙星相仿。AIM: To compare the efficacy and safety of gatifloxacin with levofloxacin in the treatment of urinary tract infections. METHODS: Using levofloxacin as a contrast medicine, 48 patients were enrolled to carry out arandomized, double simulation, double blind, parallel controlled trial (n=24) group A was given gatifloxacin 400 mg, qd, for 7-14 d group B (n=24) was given levofloxacin 400 mg, qd, for 7-14 d. RESULTS: The clinical cured rate and effective rate in group A were 100 % and 100 % respectively, and thoses in group B were 92 % and 92 %, respectively. There was no statistical difference between the two groups (P>0.05). The bacterial clearance rate was 100 % in two groups, and that was also no significant difference (P>0.05). The adverse reaction rates were 8 % and 12 % respectively in group A and B without statistical difference (P>0.05). CONCLUSION: The efficacy and safety of gatifloxacin is similar to those of levofloxacin for treatment of urinary tract infections.

关 键 词：氧氟沙星 泌尿道感染 随机对照试验 加替沙星 

分 类 号：R978.1[医药卫生—药品] R691.3[医药卫生—药学]