聚碳酸酯型聚氨酯的体外降解研究  

RESEARCH ON ENZYMATIC DEGRADATION OF POLY(CARBONATE)URETHANES IN VITRO

作　　者：李洁华[1] 谭鸿[1] 谢兴益[1] 何成生[1] 樊翠蓉[1] 钟银屏[1] 

机构地区：[1]四川大学高分子科学与工程学院,成都610065

出　　处：《中国生物医学工程学报》2004年第4期300-304,共5页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金资助项目(59973013)

摘　　要：本研究聚碳酸酯型聚氨酯(PCU),在预氧化处理后(5%H2O2/0.05M CoCl2溶液),再用酶(番木瓜蛋白酶,20U/ml的溶液)水解处理后的表面形态及分子结构变化,同时与聚醚聚氨酯(PEU)和氟碳化合物封端的聚碳酸酯型聚氨酯(PCUF)材料作对比。通过扫描电镜(SEM),光电子能谱(XPS)和分子量(GPC)表征材料表面降解情况和分子结构变化。结果证实了材料的抗氧化性能直接影响材料的整体降解情况,结果显示PCU抗氧化性能优良,所以它的整体抗降解能力比抗氧化能力较低的PEU强,而且在PCU中引入氟碳化合物,其抗降解能力会更强。Three polyurethanes including poly (carbonate)urethanes, poly (ether)urethanes and fluorocarbon end-capped poly (carbonate) urethane were used as model polymers. Each material was subjected to the treatments of oxidative (5%H2O2/0.05M CoCl2), enzymatic (with papain), and oxidative followed by enzymatic treatment vespe ctively The degradable effects were examined by scanning electron microscope (SEM), X-photo electron spectra (XPS) and gel-permeation chromatography (GPC). In conclusion, the extent of overall degradation was influenced by the oxidation stability of the material. Oxidative pretreated PEU was susceptible to enzymatic degradation, but PCU and PCUF were less attacked by enzyme because of their resistance to oxidation.

关 键 词：聚氨酯 聚碳酸酯型聚氨酯 氟碳化合物 酶降解 

分 类 号：R318.08[医药卫生—生物医学工程]