氮酮促进复方替硝唑凝胶经皮渗透作用研究  

Study of Azone in Percutaneous Permeation of Compound Tinidazole Gel

作　　者：张永军[1] 于志庚[1] 胡志林[1] 

机构地区：[1]新疆石河子大学医学院附属第一医院,石河子市832008

出　　处：《中国药房》2004年第9期537-538,共2页China Pharmacy

摘　　要：目的 :研究不同浓度的氮酮对复方替硝唑凝胶透皮吸收的作用 ,并筛选出最佳浓度。方法 :采用垂直式Franz扩散池 ,以不同浓度的氮酮作为促渗剂 ,应用反相高效液相色谱法测定处方中替硝唑、氯霉素、水杨酸3组分的含量并计算其单位面积累积透皮量。结果与结论 :不同浓度的氮酮对复方替硝唑凝胶中3组分的渗透性均有促进作用 ,其中浓度为2 %的氮酮透皮促渗作用最显著。OBJECTIVE:To study the enhancing effects of azone at different concentrations on percutaneous permeation of compound tinidazole gel and to find out the best concentration.METHODS:Using vertical Franz-type diffusion cell and difˉferent concentrations of azone as enhancer,the concentrations of tinidazole,chloramphenicol and salicylic acid in permeation solution were measured by RP-HPLC,then cumulative permeation quantity(Q)was calculated.RESULTS&CONCLUSION:Azone at different concentrations could promote the permeability of3ingredients of compound tinidazole gel,and2%azone had the most obvious permeation-enhancing effect.

关 键 词：复方替硝唑凝胶 氮酮 透皮吸收 反相高效液相色谱法 

分 类 号：R965[医药卫生—药理学]