益气活血方对心梗后左室重构大鼠血PCⅢ、TNF-α、ET-1的影响  

Effects of "Yiqi Huoxue Decoction" on Serum PC Ⅲ, TNF-α and ET-1 in Rats After Myocardial Infarction with Left Ventricular Remodeling

作　　者：韩丽华[1] 王振涛[1] 吴鸿[2] 李娟[2] 

机构地区：[1]河南省中医院心血管病研究所,河南郑州450002 [2]河南中医学院,河南郑州450008

出　　处：《上海中医药杂志》2004年第9期50-52,共3页Shanghai Journal of Traditional Chinese Medicine

基　　金：河南省科技攻关课题 (0 12 4 170 72 3)

摘　　要：为研究益气活血方 (主药 :人参、黄芪、黄精、赤芍药、西红花 )的作用机理 ,观察该方对心梗后左室重构大鼠外周血PCⅢ、TNF α、ET 1水平的影响。Wistar雄性大鼠建立心梗模型后 ,分为 5组 ,即益气活血方大、小剂量组 ,卡托普利组 ,模型组 ,假手术组 ,分别以相应药物灌胃 3个月 ,于腹主动脉采血测定PCⅢ、TNF α、ET 1的含量。结果 :与假手术组相比 ,模型组大鼠PCⅢ、TNF α、ET 1水平均明显升高(P <0 0 5 ) ;所有给药组对PCⅢ、TNF α、ET 1水平均有不同程度的降低作用 ,其中益气活血方大剂量组和卡托普利组的作用尤为明显 (P <0 0 5 )。结论 :益气活血方能够抑制心梗后大鼠心肌纤维化 ,抑制血浆ET 1增加 ,拮抗TNF α。推测这是该方干预心梗后左室重构的作用机制之一。To observe the effects of 'Yiqi Huoxue Decoction' on serum PC Ⅲ, TNF-α and ET-1 in rats after myocardial infarction with left ventricular remodeling, acute myocardial infarction was modeled in rats. The rats were divided into five groups: large dose group, small dose group, captopril group, model group and sham group, and treated accordingly for three months. Serum PC Ⅲ, TNF-α and ET-1 measured. Results: Compared to sham group, the levels of serum PC Ⅲ, TNF-α and ET-1 increased obviously (P<0.05), especially in large dose group and captoril group. It is revealed that the Decoction acts to intervene left ventricular remodeling possibly by reducing the levels of PC Ⅲ, TNF-α and ET-1.

关 键 词：益气活血方 心肌梗死 大鼠模型 左室重构 Ⅲ型前胶原 肿瘤坏死因子α 内皮素 

分 类 号：R285[医药卫生—中药学]