低氧诱导因子-1α的表达调控  

Regulation of Hypoxia-Inducible Factor-1á Expression

作　　者：杜可明[1] 陈国强[1] 陈竺[1] 

机构地区：[1]上海第二医科大学附属瑞金医院上海血液学研究所,上海200025

出　　处：《癌症》2004年第9期1098-1102,共5页Chinese Journal of Cancer

基　　金：国家重点基础研究发展计划973项目(No.2002CB512806)~~

摘　　要：低氧诱导因子-1(hypoxia-induciblefactor-1,HIF-1)是调节氧稳态的核心转录因子,在机体的生理和病理过程中起着关键作用,在肿瘤形成中也起着非常重要的作用。它是由α、β两个亚基组成的异二聚体,其活性主要由HIF-1α亚基来决定,而α亚基的DNA结合活性和转录活性又受到严格调控。这些调控因素除氧浓度外,还包括其它刺激物如金属离子、NO、活性氧和生长因子等。本文概述HIF-1α表达调控的分子机制。Hypoxia-inducible factor-1(HIF-1) is a major transcriptional re gu lator of O2 homeostasis, and plays a key role in physiology, and pathophysiology , and also in tumor pathogenesis. HIF-1 is a heterodimer consisting of HIF-1á and asubunits. The activities of HIF-1 is mainly determined by HIF-1á, which transcriptional activity and DNA-binding ability were strictly regulated by O2 concentration, and other stimuli such as metalion, nitric oxide(NO), reactive o xygen species (ROS), and many growth factors. Here we reviewed the mechanisms of regulation of HIF-1áexpression.

关 键 词：低氧诱导因子-1 基因调控 信号传导 

分 类 号：R346[医药卫生—基础医学]