壬基酚对大鼠睾丸和血清中某些生化指标的影响  

Changes of certain biochemical indexes in rats' testis and serum after nonylphenol treatment

作　　者：段志文[1] 崔金山[1] 张玉敏[1] 朱明艳[2] 王睿[2] 

机构地区：[1]沈阳医学院毒理学教研室 [2]沈阳医学院附属中心医院检验科,110018

出　　处：《中国职业医学》2004年第1期23-24,共2页China Occupational Medicine

摘　　要：目的　研究环境类激素壬基酚对大鼠睾丸和血清中某些生化指标的影响。方法　以壬基酚 50、10 0、2 0 0mg/kg剂量对Wistar雄性大鼠连续经口染毒 3 5d ,检测大鼠睾丸组织匀浆及血清中 β -葡萄糖醛酸苷酶 (β G)、乳酸脱氢酶同工酶 (LDHx)、超氧化物歧化酶 (SOD)的活性及谷胱甘肽 (GSH)、丙二醛 (MDA)含量 ,血中睾酮 (T)、雌二醇 (E2 )水平。结果　 50mg/kg处理组睾丸组织中 β G和 2 0 0mg/kg处理组血清中LDHx活性显著高于对照组 (P <0 0 5) ;2 0 0mg/kg处理组睾丸组织中SOD活性及血中T含量显著低于对照组 (P <0 0 5)。结论　壬基酚可能会诱发大鼠睾丸和血清某些生化指标的改变 。ObjectiveTo study the change of some bioch em ical indexes in testis homogenate and serum of male rats treated with nonylpheno l (NP). MethodsThe activities or levels of β-glucuronidase ( β-G), lactate dehydrogenase isoenzyme-x (LDHx), superoxide dismutase (SOD ), g lutathione (GSH), malondialdehyde (MDA), testosterone (T) and estradiol (E 2) i n serum and testis homogenate in rats treated with NP orally at dose of 50,100, 20 0 mg/kg for 35 days respectively. ResultsAfter 35 days, the ac tivities of β-G in testis homogenate at dose of 50 mg/kg and LDHx in serum at dose of 200 mg/kg were higher than those in control ( P <0 05). The act ivities of SOD in testis homogenate and the levels of T in serum at dose of 200 mg/kg were lower than those in control ( P <0 05). Conclusion Nonylphenol could induce testis damage of male rats.

关 键 词：壬基酚 大鼠 睾丸损伤 

分 类 号：R135[医药卫生—劳动卫生]