针刺督脉穴对拟AD大鼠海马区AchE、ChAT活性的影响  

Effect of Acupuncture on AchE and ChAT Activity of Hippocampus of Rats

作　　者：王少锦[1] 李爱英[2] 张雪静[2] 

机构地区：[1]河北医科大学中医学院 [2]河北医科大学基础医学院,河北石家庄050091

出　　处：《南京中医药大学学报》2004年第5期289-291,共3页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：河北省中医药管理局计划项目 ( 2 0 0 10 7)

摘　　要：目的　探讨针刺对拟AD大鼠大脑海马胆碱能神经功能的影响。方法　应用迷宫试验观测针刺对拟AD大鼠学习记忆能力的影响 ;并分别采用巯基比色分析法和免疫组化方法测定大鼠海马区乙酰胆碱酯酶 (AchE)和胆碱乙酰化酶(ChAT)活性的变化。结果　针刺组大鼠海马区AchE、ChAT活性比模型组有显著提高 (P <0 .0 1)。经迷宫学习记忆能力测试 ,针刺组大鼠成绩好于模型组 (P <0 .0 1)。结论　针刺督脉穴可增强海马区AchE和ChAT活性 ,改善拟AD大鼠的记忆功能障碍。OBJECTIVE To explore into the effect of acupuncture on AchE and ChAT activity of the hippocampus of rats. METHOD Labyrinth test was used to observe the effect of acupuncture on the learning ability of rats and hydrosulfide colorimetric analysis and immune composition method were used respectively to determine changes in AchE and ChAT activity. RESULT In the acupuncture group, there was greater changes in the AchE and ChAT activity than in the model group (P<0.01). Through labyrinth test it was found that the learning ability of the rats in the acupuncture group was better than the model group (P<0.01). CONCLUSION Acupuncture at points on Du Meridian can improve the memory of rats.

关 键 词：针刺 督脉穴 原发性老年痴呆症 大鼠大脑海马区 乙酰胆碱酯酶 胆碱乙酰化酶 

分 类 号：R246.6[医药卫生—针灸推拿学]