甲磺酸罗哌卡因与盐酸罗哌卡因硬膜外麻醉的临床研究(英文)  

Clinical comparison of the efficacy and safety of epidural ropivacaine mesylate and ropivacaine hydrochloride

作　　者：徐建青[1] 朱波[1] 叶铁虎[1] 吴新民[2] 秦翔[2] 王庚[2] 许幸[2] 于布为[3] 李一亮[3] 周静芳[3] 王玉萍[3] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院麻醉科,北京100730 [2]北京大学第一医院麻醉科,北京100034 [3]上海第二医科大学附属瑞金医院麻醉科,上海200025

出　　处：《中国临床药理学与治疗学》2004年第8期872-875,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的 :比较甲磺酸罗哌卡因与盐酸罗哌卡因硬膜外麻醉的Ⅱ期临床效果和安全性。方法 :3个中心 12 4例择期在低位硬膜外麻醉下行经腹子宫切除术、膀胱部分切除术等手术的患者随机均分为 2组 :A组注入 0 .75 %盐酸罗哌卡因 15ml,B组注入0 .894 %甲磺酸罗哌卡因 15ml。结果 :不论是在感觉和运动阻滞的起效时点分布、效果及效果维持时长方面 ,还是在维持相对稳定的循环、呼吸、肝肾功能等方面 ,甲磺酸罗哌卡因均表现出良好的作用 ,与盐酸罗哌卡因无明显差异 ,二者均无严重不良反应。结论 :甲磺酸罗哌卡因与盐酸罗哌卡因具有相似的硬膜外麻醉的临床效果和安全性。AIM: To compare the efficacy and security of epidural ropivacaine mesylate clinically with ropivacaine hydrochloride in a randomized double-blind multicentre study. METHODS: One hundred and twenty-four elective patients from three centres, undergoing lower epidural anesthesia for intraperitoneal hysterectomy, partial cystectomy and so on, were randomly assigned to two equal groups received 15 ml of either 0.75% ropivacaine hydrochloride or 0.894% ropivacaine mesylate. RESULTS: There were no significant differences found in the onset, extent, and duration of sensory and motor block, and also in the hemodynamic stability. When ropivacaine mesylate was clinically compared with ropivacaine hydrochloride. No serious adverse events were found in this study. CONCLUSION: Epidural ropivacaine mesylate is similar to ropivacaine hydrochloride in both efficacy and safety.

关 键 词：麻醉 硬膜外 局部麻醉药 甲磺酸罗哌卡因 盐酸罗哌卡因 

分 类 号：R969[医药卫生—药理学]