国产那格列奈片对2型糖尿病疗效的临床评价  

Clinical evaluation on efficacy of domestic nateglinide tablet in patients with type 2 diabetes mellitus

作　　者：夏礼斌 陆美琴[1] 张斌华[1] 张安素[1] 陈月平[1] 华强[1] 冒国光 

机构地区：[1]皖南医学院弋矶山医院内分泌科 [2]国家药品临床研究基地

出　　处：《中国临床药理学与治疗学》2004年第8期932-934,共3页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的 :评价国产那格列奈片治疗 2型糖尿病的疗效。方法 :4 6例 2型糖尿病患者随机分入那格列奈组和瑞格列奈组 ,以瑞格列奈作阳性对照 ,检测空腹血糖及糖化血红蛋白 (HbA1C)。结果 :两组治疗后空腹指尖及静脉血糖、糖化血红蛋白均有所下降 ,治疗 8周后瑞格列奈组空腹指尖血糖改善值优于那格列奈组。结论 :那格列奈片能改善 2型糖尿病患者的糖代谢 ,是一种安全有效的降糖药物。AIM: To evaluate the efficacy of domestic nateglinide tablet with the treatment of patients with type 2 diabetes mellitus (T 2DM). METHODS: Forty-six patients of T 2DM were included in this study. The twenty-three patients in nateglinide group took nateglinide tablet, and another twenty-three patients in the repaglinide group took repaglinide tablet. The changes of both fasting blood glucose and hemoglobin A 1C(HbA 1C) levels were assayed. RESULTS: After the treatment of 12 weeks, the levels of fasting blood glucose and HbA 1C decreased significantly (P< 0.01). After 8th weeks, the levels of fasting blood glucose of repaglinide group on finger-tip decreased significantly than those of the nateglinide group. CONCLUSION: Domestic nateglinide, as an effective and safe agent, can improve the glycometabolism in treating T 2DM.

关 键 词：那格列奈 瑞格列奈 2型糖尿病 空腹血糖 糖化血红蛋白 

分 类 号：R977.15[医药卫生—药品] R969.4[医药卫生—药学]