基质衍生因子1等基因多态性在人群中的分布  

Distribution of SDF 1-3' A,CCR2-64I and -2518MCP-1 polymorphism in population

作　　者：胡以松[1] 李向培[2] 杨仕贵[1] 张国庆[1] 叶冬青[1] 

机构地区：[1]安徽医科大学流行病与卫生统计学系,合肥230032 [2]安徽省立医院风湿科

出　　处：《中国公共卫生》2004年第1期17-19,共3页Chinese Journal of Public Health

基　　金：安徽省教育厅重点科研项目 ( 2G 0 2kj75ZD );安徽省自然科学基金项目 (984 372 31 )

摘　　要：目的　探讨SDF1-3’A、CCR2 -64I、-2 518MCP -1基因多态性在皖籍汉族人群中的分布。方法　运用PCR -RFLP方法确定SDF1-3 /A和 -2 518MCP -1基因多态性 ,运用ARMS方法确定CCR2 -64I基因多态性。结果　皖籍汉族人 -2 518MCP -1G等位基因突变频率为 64% ,高于西班牙人、美国黑人、高加索人 ,均有显著性差异(P <0 0 1)。CCR2 -64I等位基因突变频率为 2 5% ,高于美国黑人和高加索人 (P <0 0 1)。SDF1-3’A等位基因突变频率为 2 2 % ,高于美国黑人 ,但与国内其他地区均无显著性差异 (P <0 0 5)。结论　皖籍汉族人 -2 518MCP -1、CCR2 -64I。ObjectiveTo investigate the distribution of SDF 1-3' A,C CR 2-64I and -2518MCP-1 polymorphism in the indigenous Han population of Anhui p rovince.MethodsThe polymorphism of SDF 1-3'A,CCR2-64I and -2518M CP-1 was dete rmined by PCR-RFLP and ARMS (amplification refractory mutation sys tem) respectively.ResultsThe frequency of -2518MPC-1G in Anhui Han Amerian s ( P <0\^01).There was significant difference in frequency of CCR2-64I betwee n Caucasian and African Amerians and Anhui Han population (25%),and the frequenc y of SDF 1-3'A (22%) in Anhui Han population was higher than that of African Ame rians.But there was no significant difference between Anhui Han population and o thers areas in China.ConclusionThe frequency of -2518MCP-1,CCR2-64I and SDF 1 -3' A in Anhui Han population was different from others population in the world.

关 键 词：基质衍生因子1 趋化性细胞因子受体2 单核趋化蛋白1 基因多态性 

分 类 号：R392.13[医药卫生—免疫学]